AI Article Synopsis
- CPEB3 is highlighted as a key regulator in learning and memory, supported by various studies on behavior, brain activity, and brain structure.
- The review discusses CPEB3's interaction with important proteins like AMPA and NMDA receptors, actin, and PSD95, which are vital for synaptic plasticity.
- It also explores the molecular mechanisms influencing CPEB3's functions, including regulatory proteins, modifications, and structural features essential for its role in sustaining synaptic changes linked to long-term memory.
Article Abstract
The cytoplasmic polyadenylation element-binding (CPEB) protein family have demonstrated a crucial role for establishing synaptic plasticity and memory in model organisms. In this review, we outline evidence for CPEB3 as a crucial regulator of learning and memory, citing evidence from behavioral, electrophysiological and morphological studies. Subsequently, the regulatory role of CPEB3 is addressed in the context of the plasticity-related proteins, including AMPA and NMDA receptor subunits, actin, and the synaptic scaffolding protein PSD95. Finally, we delve into some of the more well-studied molecular mechanisms that guide the functionality of this dynamic regulator both during synaptic stimulation and in its basal state, including a variety of upstream regulators, post-translational modifications, and important structural domains that confer the unique properties of CPEB3. Collectively, this review offers a comprehensive view of the regulatory layers that allow a pathway for CPEB3's maintenance of translational control that guides the necessary protein changes required for the establishment and maintenance of lasting synaptic plasticity and ultimately, long term learning and memory.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425470 | PMC |
| http://dx.doi.org/10.18632/aging.103404 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Learned phenotypes emerge during social stress modifying hippocampal orexin receptor gene expression.
Sci Rep
December 2024
Department of Biology, University of South Dakota, 414 East Clark Street, Vermillion, SD, 57069-2390, USA.
Psychological distress, including anxiety or mood disorders, emanates from the onset of chronic/unpredictable stressful events. Symptoms in the form of maladaptive behaviors are learned and difficult to treat. While the origin of stress-induced disorders seems to be where learning and stress intersect, this relationship and molecular pathways involved remain largely unresolved.
View Article and Find Full Text PDFEngagement in moderate-intensity physical activity supports overnight memory retention in older adults.
Sci Rep
December 2024
Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, USA.
Preserving the ability to vividly recall emotionally rich experiences contributes to quality of life in older adulthood. While prior works suggest that moderate-intensity physical activity (MPA) may bolster memory, it is unclear whether this extends to emotionally salient memories consolidated during sleep. In the current study, older adults (mean age = 72.
View Article and Find Full Text PDFPattern memory cannot be completely and truly realized in deep neural networks.
Sci Rep
December 2024
School of Artificial Intelligence and Computer Science, Jiangnan University, Wuxi, 214122, China.
The unknown boundary issue, between superior computational capability of deep neural networks (DNNs) and human cognitive ability, has becoming crucial and foundational theoretical problem in AI evolution. Undoubtedly, DNN-empowered AI capability is increasingly surpassing human intelligence in handling general intelligent tasks. However, the absence of DNN's interpretability and recurrent erratic behavior remain incontrovertible facts.
View Article and Find Full Text PDFPreventive effect of Tyr-Pro, a blood-brain barrier transportable dipeptide, on memory impairment in SAMP8 mice.
NPJ Sci Food
December 2024
Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka, Japan.
In a series of studies on blood-brain barrier transportable peptides, a soybean dipeptide, Tyr-Pro, penetrated the mouse brain parenchyma after oral intake and improved short and long memory impairment in acute Alzheimer's model mice. Here, we aimed to clarify the anti-dementia effects of this peptide administered to SAMP8 mice prior to dementia onset. At the end of the 25-week protocol in 16-week-old SAMP8 mice, Tyr-Pro (10 mg/kg/day) significantly improved the reduced spatial learning ability compared with that in the control and amino acid (Tyr + Pro) groups as indicated by the results of Morris water maze tests conducted for five consecutive days.
View Article and Find Full Text PDFCerebellar-driven cortical dynamics can enable task acquisition, switching and consolidation.
Nat Commun
December 2024
Computational Neuroscience Unit, Intelligent Systems Labs, Faculty of Engineering, University of Bristol, Bristol, UK.
The brain must maintain a stable world model while rapidly adapting to the environment, but the underlying mechanisms are not known. Here, we posit that cortico-cerebellar loops play a key role in this process. We introduce a computational model of cerebellar networks that learn to drive cortical networks with task-outcome predictions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!