AI Article Synopsis
- Arthrofibrosis is an abnormal condition where excessive scar tissue forms around a joint, often due to injury, surgery, or even spontaneously.
- The exact cause is not fully understood, but it involves the disruption of the body's normal healing processes, particularly influenced by a protein called TGF-beta.
- Current treatments include physical therapy and surgery, but none are completely effective, leading to a search for new drug therapies to help manage the condition.
Article Abstract
* Arthrofibrosis is a pathologic condition that is characterized by excessive periarticular scar-tissue formation. Arthrofibrosis may occur secondary to injury, surgical trauma, hemarthrosis, or infection, or it may occur idiopathically.* The pathogenesis of arthrofibrosis is incompletely understood but involves the dysregulation of normal reparative pathways, with transforming growth factor-beta (TGF-[beta]) as a principal mediator.* Current treatment options for arthrofibrosis primarily involve physiotherapy, operative manipulation, and surgical debridement, all with imperfect results.* Currently, there are no pharmacologic treatment options for arthrofibrosis. This has prompted increased investigational interest in the development of antifibrotic intra-articular therapies.
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| http://dx.doi.org/10.2106/JBJS.RVW.19.00223 | DOI Listing |
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