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d-Amphetamine and Feeding States Cohesively Affect Locomotion and Motor Neuron Response in Zebrafish Larvae.
Brain Behav
December 2024
Department of Mechanical and Industrial Engineering, The University of Illinois at Chicago, Chicago, Illinois, USA.
Purpose: Amphetamine (AMPH) increases locomotor activities in animals, and the locomotor response to AMPH is further modulated by caloric deficits such as food deprivation and restriction. The increment in locomotor activity regulated by AMPH-caloric deficit concomitance can be further modulated by varying feeding schedules (e.g.
View Article and Find Full Text PDFAdverse effects of glyphosate-based herbicide on hatching rate, morphological alterations, and acetylcholinesterase (AChE) expression in golden apple snail eggs.
Aquat Toxicol
December 2024
Department of Fisheries, Faculty of Agriculture and Technology, Rajamangala University of Technology Isan Surin Campus, Surin 32000 Thailand. Electronic address:
Article Synopsis
- This research examined how glyphosate herbicide affects golden apple snail eggs, specifically looking at hatching rates, physical changes, and the expression of the enzyme acetylcholinesterase (AChE) as an exposure biomarker.
- The study found that higher concentrations and longer exposure to glyphosate led to decreased hatching success and morphological defects in the eggs, as revealed through various analytical methods such as optical coherence tomography.
- Key bioactive components in the eggs were characterized, showing that glyphosate exposure reduced these protective substances, which may have consequences for snail populations and the health of aquatic ecosystems.
Selective dopamine D3 receptor partial agonist (±)VK4-40 reduces the reinforcing strength of d-amphetamine but not cocaine in rhesus monkeys responding under a progressive-ratio schedule of reinforcement.
Drug Alcohol Depend
December 2024
Department of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. Electronic address:
Background: Although countless studies have aimed to identify and test novel therapeutics for stimulant misuse, there are still no FDA-approved pharmacotherapies for stimulant use disorders. One potential treatment target is the dopamine D3 receptor (D3R) and studies in rodents have suggested that the novel D3R partial agonist (±)VK4-40 may be effective at decreasing cocaine self-administration. However, no previous studies have examined the efficacy of (±)VK4-40 in reducing cocaine self-administration in nonhuman primates nor the generality of effects by examining self-administration of other stimulants using a within-subjects design.
View Article and Find Full Text PDFAmphetamine-Dextroamphetamine-Induced Cardiomyopathy: A Case Report on Heart Failure in a Young Addict.
Cureus
October 2024
Cardiology, Althager General Hospital, Jeddah, SAU.
Article Synopsis
- * A case study of a 32-year-old man revealed his heart failure with reduced ejection fraction was associated with amphetamine use, raising concerns about drug-induced deterioration of existing heart conditions.
- * Effective management of patients with ADHD and heart issues requires careful monitoring by a multidisciplinary team and a complete pharmaceutical regimen to prevent further cardiac problems.
Effect of bariatric surgery on the pharmacokinetics of drugs used for attention-deficit hyperactivity disorder-A case series.
Basic Clin Pharmacol Toxicol
January 2025
Department of Clinical Pharmacology, Clinic of Laboratory Medicine, St. Olav University Hospital, Trondheim, Norway.
Background: Changes in gastrointestinal physiology following bariatric surgery may affect the pharmacokinetics of drugs. Data on the impact of bariatric surgery on drugs used for attention-deficit/hyperactivity disorder (ADHD) are limited.
Methods: In patients treated with ADHD medication and undergoing bariatric surgery, serial drug concentrations were measured for 24 h preoperatively and one, six and 12 months postoperatively.
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