LncRNA promotes taxane resistance in castration-resistant prostate cancer via a BCL2A1-dependent mechanism.

Castration-resistant prostate cancer (CRPC) is an incurable malignancy. Long noncoding RNAs (lncRNAs) play key roles in drug resistance. LncRNA role in cabazitaxel resistance (i.e., cell-count, IC and caspase activity) was studied via lentiviral-mediated overexpression and siRNA-based knockdown. Genes expression was analyzed with RNA-sequencing, reverse transcription quantitative PCR (RT-qPCR) and western blot. expression was queried in clinical database. Cabazitaxel increased expression that upregulated , thereby protecting CRPC cells from cabazitaxel-induced apoptosis. knockdown decreased cell-count and increased apoptosis in CRPC cells. -targeting antisense oligonucleotide decreased cabazitaxel IC. In CRPC clinical samples, expression increased upon taxane treatment. stimulates the expression of BCL2A1 thereby decreasing apoptosis and enhancing cabazitaxel resistance in CRPC cells.