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Treatment Options for Nosocomial Ventriculitis/Meningitis: A Case Report and Review of the Literature.
Pathogens
December 2024
Intensive Care Unit, Department of Anesthesiology and Critical Care, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Ventriculo-meningitis or nosocomial meningitis/ventriculitis is a severe nosocomial infection that is associated with devastating neurological sequelae. The cerebrospinal fluid isolates associated with the infection can be Gram-positive or -negative, while the spp. is rarely identified.
View Article and Find Full Text PDFAcute Humoral Rejection 12 Days Post-Heart Transplantation with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antigen Expression in Myocardial Tissue: A Clinical Case.
Turk Kardiyol Dern Ars
December 2024
Almazov National Medical Research Centre, St. Petersburg, Russia.
Article Synopsis
- The study details a case of acute humoral rejection (AMR) in a heart transplant patient who had a history of hypertrophic cardiomyopathy and chronic myocarditis.
- After the transplant, the patient faced complications like pneumonia, leading to reduced immunosuppressive therapy.
- Tragically, the patient suffered a fatal hemodynamic collapse linked to autopsy findings of AMR with significant presence of CD16+ cells and SARS-CoV-2 Spike protein, highlighting the need for further research on the virus's impact on AMR.
Genomic epidemiological analysis of a single-centre polyclonal outbreak of , Belgium, 2022 to 2023.
Euro Surveill
November 2024
Laboratory of Medical Microbiology, Vaccine and Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium.
Article Synopsis
- An opportunistic pathogen caused an 18-month outbreak in a neonatal intensive care unit (NICU) in Antwerp, Belgium, affecting 61 neonates, with ten confirmed infections resulting in serious conditions, including one fatal case.
- The risk of acquiring the infection was significantly higher in neonates nursing in incubators, highlighted by statistical analysis (OR: 2.99; p < 0.05).
- Whole genome sequencing revealed multiple clusters and the importance of ongoing surveillance and specific infection control measures in NICUs to prevent similar outbreaks in the future.
Crimean-Congo haemorrhagic fever among healthcare workers in Iran 2000-2023, a report of National Reference Laboratory.
BMC Infect Dis
November 2024
Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, 1316943551, Iran.
Background: Crimean-Congo haemorrhagic fever (CCHF) is a lethal acute viral zoonosis with a case fatality rate of 5-50%. Due to the potential of human-to human transmission of the disease, healthcare workers (HCWs) are at risk of occupational exposure to CCHF virus. Little is known about CCHF virus route of transmission and risks in Iranian HCWs.
View Article and Find Full Text PDFPseudomonas aeruginosa elongation factor-Tu (EF-Tu) is an immunogenic protective protein antigen.
Vaccine
December 2024
Emory-Children's Cystic Fibrosis Center, Division of Pulmonary, Asthma, Cystic Fibrosis, and Sleep, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. Electronic address:
Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen that infects immunocompromised individuals, especially in the hospital setting. This bacterium is an important pathogen in people with weakened immune systems, injuries, and other underlying physiologic dysfunctions. P.
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