The healing time of leprosy lesions in 117 paucibacillary (PB) cases who took no antileprosy treatment was estimated to be 2.03 +/- 0.10 (mean +/- S.E.) years in a leprosy hyperendemic area. This healing time does not appear to be influenced by epidemiological characteristics of the patients such as age, sex, intrafamilial leprosy contact status, number and site of leprosy lesions, etc. It was also observed that the rate of healing and downgrading among the total untreated cases was 22.4% and 0.57%, respectively, per year. About 39% of the total untreated PB leprosy cases healed within a period of 2 years. The scientific implication of this observation is discussed.
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J Mater Chem B
January 2025
National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610065, P. R. China.
Wound healing is a complex and dynamic biological process that requires meticulous management to ensure optimal outcomes. Traditional wound dressings, such as gauze and bandages, although commonly used, often fall short in their frequent need for replacement, lack of real-time monitoring and absence of anti-inflammatory and antibacterial properties, which can lead to increased risk of infection and delayed healing. Here, we address these limitations by introducing an innovative hydrogel dressing, named PHDNN6, to combine wireless Bluetooth temperature monitoring and light-triggered nitric oxide (NO) release to enhance wound healing and management.
View Article and Find Full Text PDFJ Tissue Eng
January 2025
Department of Spinal Surgery, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Rotator cuff tendon injuries often lead to shoulder pain and dysfunction. Traditional treatments such as surgery and physical therapy can provide temporary relief, but it is difficult to achieve complete healing of the tendon, mainly because of the limited repair capacity of the tendon cells. Therefore, it is particularly urgent to explore new treatment methods.
View Article and Find Full Text PDFCancer Manag Res
January 2025
Department of Gynecologic Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, People's Republic of China.
Purpose: Cervical cancer is the fourth leading cause of cancer-related death in women. Furthermore, owing to its significant risk of recurrence or metastasis, the overall prognosis of patients with cervical cancer remains poor. Activating transcription factor 5 (ATF5) plays a crucial role in cell proliferation, survival, and apoptosis, and has been implicated in the progression of various types of cancer.
View Article and Find Full Text PDFFront Pharmacol
January 2025
Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Introduction: Colorectal cancer (CRC) is a leading cause of cancer-related mortality globally. Although tumor immunotherapy is widely recognized for treating unresectable CRC, challenges such as ineffective immunotherapy and drug resistance remain prevalent. While intratumor microbiome-derived butyrate has been implicated in promoting lung cancer metastasis, its role in CRC chemoresistance is not well understood.
View Article and Find Full Text PDFJB JS Open Access
January 2025
Department of Orthopedic Trauma, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People's Republic of China.
Background: The objective of this study was to compare the clinical outcomes of robot-assisted retrograde elastic intramedullary nailing and open reduction and internal fixation (ORIF) with a plate for displaced midshaft clavicular fractures.
Methods: All patients diagnosed with displaced midshaft clavicular fractures between November 1, 2022, and June 30, 2023, in our level-III hospital (most advanced level) were enrolled in this retrospective study; a total of 116 patients met the inclusion criteria. Patients were divided into 2 groups on the basis of treatment: robot-assisted retrograde elastic intramedullary nailing (RAN group) and ORIF with a plate (plate group).
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