AI Article Synopsis
- The study examined how different feeding methods (breastfeeding, formula feeding, and mix feeding) influence obesity-related gene expression in infants aged 5-6 months.
- Involving 150 healthy infants, the research found that those who were exclusively breastfed had lower weights and different gene expression levels than those who were formula-fed or mix-fed.
- The results suggested that breastfeeding may help reduce the risk of obesity and related health issues, but further research is needed to understand the full effects of breast milk on gene expression.
Article Abstract
Purpose: The study aimed to investigate the effect of breastfeeding, formula feeding and mix feeding (breastfed plus formula-fed) on the expression level of obesity-predisposing genes including fat mass and obesity-associated (), carnitine palmitoyltransferase 1A (), and peroxisome proliferator-activated receptor-α () in 5- to 6-month-old infants.
Patients And Methods: A total of 150 infants participated in this case-control study. All subjects were healthy infants aged 5-6 months that divided into 3 groups: breastfed, formula-fed, and mix-fed. The expression level of and genes in peripheral blood mononuclear cells (PBMC) was evaluated in each group using reverse transcription-polymerase chain reaction (RT-PCR) method.
Results: Our findings showed that the current weight, height, and head circumference of infants in the formula feeding and mix feeding groups were significantly higher than those in the exclusive breastfeeding group. The expression level of and genes in formula-fed and mix-fed infants was significantly higher (p<0.001) than that in breastfed infants, while the expression level of gene was significantly lower (p<0.05).
Conclusion: Breastfeeding showed modulatory effects on the expression level of obesity-predisposing genes and can protect against obesity and subsequent non-communicable diseases. However, more investigations are required to explain the epigenetic effects of breast milk.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326192 | PMC |
| http://dx.doi.org/10.2147/DMSO.S252122 | DOI Listing |
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