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Recent Update and Drug Target in Molecular and Pharmacological Insights into Autophagy Modulation in Cancer Treatment and Future Progress.
Cells
January 2023
Department of Pathology, College of Korean Medicine, Kyung Hee University, 1-5 Hoegidong Dongdaemun-gu, Seoul 02447, Republic of Korea.
Recent evidence suggests that autophagy is a governed catabolic framework enabling the recycling of nutrients from injured organelles and other cellular constituents via a lysosomal breakdown. This mechanism has been associated with the development of various pathologic conditions, including cancer and neurological disorders; however, recently updated studies have indicated that autophagy plays a dual role in cancer, acting as a cytoprotective or cytotoxic mechanism. Numerous preclinical and clinical investigations have shown that inhibiting autophagy enhances an anticancer medicine's effectiveness in various malignancies.
View Article and Find Full Text PDFHydroxychloroquine Adsorption in Aqueous Medium Using Clinoptilolite Zeolite.
Water Air Soil Pollut
July 2022
Chemical Engineering Department, Maringa State University, Av. ColomboZona 7, Maringá, PR 579087020-900 Brazil.
Unlabelled: The presence of drugs on a large scale in aquatic matrices raises concern and requires the study of efficient technologies to remove these compounds. This study investigated the adsorption capacity of the natural zeolite clinoptilolite (CP) in removing the drug hydroxychloroquine (HCQ). Zeolite was characterized by BET, XRD, FT-IR, SEM, and pH techniques.
View Article and Find Full Text PDFPhotocatalytic degradation of hydroxychloroquine using ZnO supported on clinoptilolite zeolite.
Water Sci Technol
August 2021
Department of Chemical Engineering, State University of Maringa, Maringa 87020-900, Parana, Brazil.
The objective of this work was to evaluate the photocatalytic activity of zinc oxide catalysts supported on natural zeolite clinoptilolite for photocatalytic degradation of the drug hydroxychloroquine, used in the treatment of malaria and which has been tested in the treatment of COVID-19. To synthesize 10%ZnOCP and 15%ZnOCP catalysts, the wet impregnation methodology was used. The raw and synthesized catalysts were characterized by XRD, SEM, XRF, BET, DRS, PCZ, FT-IR and PL.
View Article and Find Full Text PDFSynthesis of modified beta bismuth oxide by titanium oxide and highly efficient solar photocatalytic properties on hydroxychloroquine degradation and pathways.
J Photochem Photobiol A Chem
October 2021
Department of Environmental Engineering, Faculty of Natural Resources and Environment, University of Birjand, Birjand, Iran.
With the outbreak of coronavirus pandemic the use of Hydroxychloroquine increased. These compounds have harmful effects on the environment, such as generation of antibiotic-resistant bacteria; therefore, their degradation has been considered as one of the environmental challenges. The purpose of this research is to synthesize heterogeneous structure of TiO/β-BiO by hydrothermal method for solar degradation of Hydroxychloroquine.
View Article and Find Full Text PDFThe role of autophagy in targeted therapy for acute myeloid leukemia.
Autophagy
October 2021
Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Although molecular targeted therapies have recently displayed therapeutic effects in acute myeloid leukemia (AML), limited response and acquired resistance remain common problems. Numerous studies have associated autophagy, an essential degradation process involved in the cellular response to stress, with the development and therapeutic response of cancers including AML. Thus, we review studies on the role of autophagy in AML development and summarize the linkage between autophagy and several recurrent genetic abnormalities in AML, highlighting the potential of capitalizing on autophagy modulation in targeted therapy for AML.
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