AI Article Synopsis
- Nonsense-mediated decay (NMD) is a way cells check that their RNA is good quality, especially in a part of the cell called the cytoplasm.
- Scientists found a special NMD process that happens for RNA made at the endoplasmic reticulum (ER), which helps proteins get made.
- A part called NBAS works with another helper called UPF1 to make sure the RNA linked to the ER is stable, especially when cells are under stress, so everything works properly.
Article Abstract
Nonsense-mediated decay (NMD) is a translation-dependent RNA quality control mechanism that occurs in the cytoplasm. However, it is unknown how NMD regulates the stability of RNAs translated at the endoplasmic reticulum (ER). Here, we identify a localized NMD pathway dedicated to ER-translated mRNAs. We previously identified NBAS, a component of the Syntaxin 18 complex involved in Golgi-to-ER trafficking, as a novel NMD factor. Furthermore, we show that NBAS fulfills an independent function in NMD. This ER-NMD pathway requires the interaction of NBAS with the core NMD factor UPF1, which is partially localized at the ER in the proximity of the translocon. NBAS and UPF1 coregulate the stability of ER-associated transcripts, in particular those associated with the cellular stress response. We propose a model where NBAS recruits UPF1 to the membrane of the ER and activates an ER-dedicated NMD pathway, thus providing an ER-protective function by ensuring quality control of ER-translated mRNAs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397857 | PMC |
| http://dx.doi.org/10.1101/gad.338061.120 | DOI Listing |
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