Introduction: Recent studies revealed -glycosylation signatures of type 2 diabetes, inflammation and cardiovascular risk factors. Most people with diabetes use medication to reduce cardiovascular risk. The association of these medications with the plasma -glycome is largely unknown. We investigated the associations of metformin, statin, ACE inhibitor/angiotensin II receptor blocker (ARB), sulfonylurea (SU) derivatives and insulin use with the total plasma -glycome in type 2 diabetes.
Research Design And Methods: After enzymatic release from glycoproteins, -glycans were measured by matrix-assisted laser desorption/ionization mass spectrometry in the DiaGene (n=1815) and Hoorn Diabetes Care System (n=1518) cohorts. Multiple linear regression was used to investigate associations with medication, adjusted for clinical characteristics. Results were meta-analyzed and corrected for multiple comparisons.
Results: Metformin and statins were associated with decreased fucosylation and increased galactosylation and sialylation in glycans unrelated to immunoglobulin G. Bisection was increased within diantennary fucosylated non-sialylated glycans, but decreased within diantennary fucosylated sialylated glycans. Only few glycans were associated with ACE inhibitor/ARBs, while none associated with insulin and SU derivative use.
Conclusions: We conclude that metformin and statins associate with a total plasma -glycome signature in type 2 diabetes. Further studies are needed to determine the causality of these relations, and future -glycomic research should consider medication a potential confounder.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333804 | PMC |
| http://dx.doi.org/10.1136/bmjdrc-2020-001230 | DOI Listing |
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