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Amlodipine-induced gingival hyperplasia in a Nepalese patient experiencing high dosages: a case report.
Ann Med Surg (Lond)
November 2024
Kathmandu University School of Medical Sciences, Dhulikhel, Kavre.
Introduction And Importance: Amlodipine is a third-generation calcium channel blocker used in the treatment of hypertension. One of the side effects associated with amlodipine is gingival hyperplasia mostly occurring at a higher dose (10 mg). There are very few cases of gingival hyperplasia associated with amlodipine at a lower dose (5 mg) or short-term administration.
View Article and Find Full Text PDFAmlodipine-Induced Gum Hypertrophy in a Hypertensive Patient.
Skinmed
September 2024
Department of Dermatology, Venereology and Leprology, AIIMS Bilaspur, Bilaspur, Himachal Pradesh, India;
Novel Insights into Amlodipine-Induced Gingival Enlargement: A Clinical and Molecular Perspective.
Pharmaceuticals (Basel)
August 2024
Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića 69, 34000 Kragujevac, Serbia.
This study aimed to identify risk factors for amlodipine-induced gingival enlargement, assess quality of life, and analyze gingival tissue. This cross-sectional study involved hypertensive patients on amlodipine, divided into groups with and without gingival enlargement. Assessments included sociodemographic data, clinical evaluations, and clinical parameters.
View Article and Find Full Text PDFTargeting SRD5A1 and MMP-2/NLRP3/TGF-β1 axis alleviates the amlodipine-induced gingival hyperplasia in rats: Emerging role of saw palmetto and folic acid.
Food Chem Toxicol
July 2024
Pharmacology & Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt. Electronic address:
Saw palmetto (SAW), the herbal drug used to treat prostatic hyperplasia, exerts its antiproliferative effects by blocking steroid 5 alpha-reductase (SRD5A1) activity, that has also been involved in gingival hyperplasia (GH) pathogenesis. Concurrently, folic acid (FA) could reduce GH prevalence via its antioxidant and anti-inflammatory effects. Thus, this study tended to assess the potential therapeutic efficacy of SAW, alone and along with FA, against amlodipine-induced gingival inflammation and overgrowth in rats.
View Article and Find Full Text PDFThe Management of Drug-Induced Gingival Enlargement in a Patient With Preexisting Periodontitis.
Cureus
January 2024
Periodontology, Sri Venkateswara Dental College and Hospital, The Tamil Nadu Dr. M.G.R. Medical University, Chennai, IND.
Antihypertensives such as amlodipine, which is a family of calcium channel blockers (CCBs), possess a limitation by causing gingival enlargement on long-term use. Gingival enlargement hinders the patient's oral hygiene maintenance and causes more plaque accumulation and inflammation. The severity of the condition is dependent on dose and duration.
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