The irradiation of red light-emitting-diode light (λ = 660 nm) to 3-acyl-2-methoxyindolizines in the presence of a catalytic amount of methylene blue triggered the photooxidation of the indolizine ring, resulting in a nearly quantitative release of alcohols or carboxylic acids within a few minutes. The method was applicable for photouncaging various functional molecules such as a carboxylic anticancer drug and a phenolic fluorescent dye from the corresponding indolizine conjugates, including an insulin-indolizine-dye conjugate.

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.orglett.0c01799DOI Listing

Publication Analysis

Top Keywords

alcohols carboxylic
8
carboxylic acids
8
indolizines enabling
4
enabling rapid
4
rapid uncaging
4
uncaging alcohols
4
acids red
4
red light-induced
4
light-induced photooxidation
4
photooxidation irradiation
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!