AI Article Synopsis
- The DNA molecule not only carries genetic information but also has important roles in biological processes and various applications, such as drug design and nanotechnology.
- Significant structural changes in DNA occur when subjected to different forces from both biological and non-biological environments.
- The study highlights findings from simulations and experiments on how DNA's structure and mechanics respond to these forces, while also suggesting potential future research directions.
Article Abstract
The DNA molecule, apart from carrying the genetic information, plays a crucial role in a variety of biological processes and finds applications in drug design, nanotechnology and nanoelectronics. The molecule undergoes significant structural transitions under the influence of forces due to physiological and non-physiological environments. Here, we summarize the insights gained from simulations and single-molecule experiments on the structural transitions and mechanics of DNA under force, as well as its elastic properties, in various environmental conditions, and discuss appealing future directions.
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| http://dx.doi.org/10.1016/j.sbi.2020.05.010 | DOI Listing |
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