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| http://dx.doi.org/10.1371/journal.pntd.0008252 | DOI Listing |
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[Prevalence and genetic characteristics of infections among HIV-positive individuals in Jiangxi Province].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
July 2024
Nanchang Municipal Center for Disease Control and Prevention, Base of National Key Laboratory for the Prevention and Control of Infectious Diseases, Nanchang, Jiangxi 330038, China.
Objective: To investigate the prevalence of infection and the distribution of parasite species and genotypes among HIV-positive individuals in Jiangxi Province.
Methods: HIV-positive individuals' sociodemographic and clinical data were collected from three AIDS designated hospitals in Jiangxi Province from January 2022 to March 2023. Subjects' stool samples were collected, and genomic DNA was extracted from stool samples.
Machine learning and explainable artificial intelligence for the prevention of waterborne cryptosporidiosis and giardiosis.
Water Res
September 2024
Laboratory of Parasitology, Veterinary Research Institute, Hellenic Agricultural Organization - DIMITRA, Thermi, Thessaloniki 57001, Greece.
Cryptosporidium and Giardia are important parasitic protozoa due to their zoonotic potential and impact on human health, and have often caused waterborne outbreaks of disease. Detection of (oo)cysts in water matrices is challenging and extremely costly, thus only few countries have legislated for regular monitoring of drinking water for their presence. Several attempts have been made trying to investigate the association between the presence of such (oo)cysts in waters with other biotic or abiotic factors, with inconclusive findings.
View Article and Find Full Text PDFEuropean ground squirrels Spermophilus citellus (Linnaeus) do not share identical Cryptosporidium spp. with North American ground squirrels.
Folia Parasitol (Praha)
July 2023
Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic.
Cryptosporidium Tyzzer, 1910 is one of the most common protistan parasites of vertebrates. The results of this study provide the first data on Cryptosporidium diversity in the European ground squirrel Spermophilus citellus (Linnaeus). A total of 128 faecal samples of European ground squirrels from 39 localities in the Czech Republic were analysed for the presence of Cryptosporidium spp.
View Article and Find Full Text PDFDetection of unusual Cryptosporidium parvum subtype in patients with gastrointestinal cancer in Egypt.
Parasitol Res
February 2023
Department of Medical Parasitology, College of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Article Synopsis
- - The study investigated the presence and genetic traits of Cryptosporidium spp. in 100 patients with gastrointestinal (GI) cancer in Egypt, comparing them to 20 healthy controls.
- - Results showed that only 7% of cancer patients tested positive for Cryptosporidium using microscopy and a specific kit, but 40% were positive through a more sensitive genetic test, suggesting underreporting with traditional methods.
- - It was found that male sex and younger age were significant risk factors for infection, and researchers identified a new subtype of C. parvum, urging further studies to better understand its genetic characteristics.
The emerging role of Deubiquitinases (DUBs) in parasites: A foresight review.
Front Cell Infect Microbiol
October 2022
Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Hajipur, India.
Before the discovery of the proteasome complex, the lysosomes with acidic proteases and caspases in apoptotic pathways were thought to be the only pathways for the degradation of damaged, unfolded, and aged proteins. However, the discovery of 26S and 20S proteasome complexes in eukaryotes and microbes, respectively, established that the degradation of most proteins is a highly regulated ATP-dependent pathway that is significantly conserved across each domain of life. The proteasome is part of the ubiquitin-proteasome system (UPS), where the covalent tagging of a small molecule called ubiquitin (Ub) on the proteins marks its proteasomal degradation.
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