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Identification of a circulating carbohydrate antigen as a highly specific and sensitive target for schistosomiasis serology.
J Clin Microbiol
January 2025
Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Unlabelled: The World Health Organization (WHO) 2030 roadmap for schistosomiasis calls for development of highly sensitive and specific diagnostic tools to continue and sustain progress towards elimination. Serological assays are excellent for sensitive detection of primary schistosome infections and for schistosomiasis surveillance in near- and post-elimination settings. To develop accurate assay formats, it is necessary to identify defined antibody targets with low cross-reactivity and potential for standardized production.
View Article and Find Full Text PDFIncidence and prevalence of traumatic and non-traumatic wounds and burns and access to wound care in Sierra Leone; data from a nationwide household survey (PRESSCO) 2020.
Heliyon
January 2025
Masanga Medical Research Unit, Masanga, Sierra Leone.
Objectives: This wound section of the PREvalence Study on Surgical COnditions (PRESSCO) determines the incidence and prevalence of wounds and burns in Sierra Leone. It further describes access to wound care and wound-related healthcare-seeking behaviour.
Methods: Between October 2019 and March 2020, a nationwide cross-sectional household survey was performed.
Schistosomiasis, a neglected tropical disease, is transmitted by freshwater snails. Interruption of transmission will require novel vector-focused interventions. We performed a genome-wide association study of African snails, , exposed to in an endemic area of high transmission in Kenya.
View Article and Find Full Text PDFEthnic and racial discrimination in maternal health care in Mexico: a neglected challenge in the search for universal health coverage.
Int J Equity Health
January 2025
Center for Health Equity in Latin America, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, Louisiana, USA.
Background: Ethnic and racial discrimination in maternal health care has been overlooked in academic literature and yet it is critical for achieving universal health coverage (UHC). There is a lack of empirical evidence on its impact on the effective coverage of maternal health interventions (ECMH) for Indigenous women in Mexico. Documenting progress in reducing maternal health inequities, particularly given the disproportionate impact of the Covid-19 pandemic on ethnic minorities, is essential to improving equity in health systems.
View Article and Find Full Text PDFElucidating on the Quaternary Structure of Viper Venom Phospholipase A Enzymes in Aqueous Solution.
Biochimie
January 2025
LAQV, REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal. Electronic address:
This study focuses on the quaternary structure of the viper-secreted phospholipase A (PLA), a central toxin in viper envenomation. PLA enzymes catalyse the hydrolysis of the sn-2 ester bond of membrane phospholipids. Small-molecule inhibitors that act as snakebite antidotes, such as varespladib, are currently in clinical trials.
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