AI Article Synopsis
- Iron is essential for cell function and visual processes in the retina, and maintaining balanced iron levels is crucial to prevent harmful effects.
- Dysregulation of iron homeostasis is linked to degenerative diseases like age-related macular degeneration (AMD).
- Research is exploring transferrin treatment to manage iron-related issues in AMD, suggesting that targeting iron could lead to new therapies.
Article Abstract
Iron has a fundamental role for cell physiology and especially in retina as a cofactor of many pathways of the visual transduction. A tightly regulated homeostasis avoids the accumulation of prooxidant and proinflammatory free iron. A dysfunction of iron retinal homeostasis is associated with many genetic or age-related degenerative diseases such as age-related macular degeneration (AMD). Here, we describe various mechanisms reported during AMD, enhanced by iron accumulation and its homeostasis dysregulation. We have investigated a local treatment with transferrin, the natural iron carrier, to control these pathological pathways and iron dysfunction, without side effects. Iron has a central role in pathogenesis of AMD and is a target for futures therapies.
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| http://dx.doi.org/10.1051/medsci/2020096 | DOI Listing |
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