AI Article Synopsis
- This study looked at how the length of telomeres (which are parts of our DNA) can help predict heart problems in people with coronary artery disease (CAD).
- They studied 366 CAD patients and 76 healthy people, finding that CAD patients had shorter telomeres. The shorter telomeres were linked to more serious heart issues.
- The results showed that measuring telomere length can help doctors identify patients at risk of having major heart problems in the near future.
Article Abstract
This study aimed to explore the prognostic value of leukocyte telomere length (LTL) in patients with coronary artery disease (CAD). We enrolled 366 CAD patients and 76 healthy subjects in this study. LTL was measured. All subjects were followed up for 6 months for further analysis regarding major adverse cardiac events (MACEs). CAD patients had a significantly shortened LTL compared with healthy subjects (p < 0.05). The area under the curve for LTL prediction of MACEs was 0.769 (p < 0.001), with a shorter LTL being an independent predictor of MACEs (Cox proportional hazards regression, hazard ratio: 2.866; p < 0.001). LTL could be considered as an independent predictor of short-term MACEs in CAD.
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| http://dx.doi.org/10.2217/bmm-2020-0171 | DOI Listing |
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