Verruciform genital-associated xanthoma with acantholysis: Report of a rare case.

JAAD Case Rep

Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, Connecticut.

Published: July 2020

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321792PMC
http://dx.doi.org/10.1016/j.jdcr.2020.05.011DOI Listing

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Article Synopsis
  • Verruciform xanthoma is a benign, wart-like lesion mainly found in the oral cavity but also occurring in the genital area, referred to as Vegas xanthomas.
  • A review of 193 cases shows they are mostly found in men (164 cases) and present as asymptomatic lesions featuring foamy histiocytes in the dermal papillae, similar to those found in the mouth.
  • Diagnosis requires a biopsy, and successful treatment typically involves complete surgical excision.
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Background: Verruciform xanthoma is a benign verrucous lesion characterized by epithelial acanthosis and lipid-laden foamy histiocytes in the connective tissue papillae. It typically presents as a papillomatous, polypoid, or sessile lesion. Verruciform xanthoma is most commonly observed within the oral cavity.

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