AI Article Synopsis
- Parkinson's disease (PD) affects 2-3% of people over 65 and mainly studies have focused on symptoms rather than the underlying neurodegeneration linked to balance issues and falls.
- Corneal confocal microscopy (CCM) is a non-invasive imaging technique that can measure nerve damage related to both peripheral and central nervous system disorders.
- Research using CCM has found that patients with PD have significantly lower corneal nerve fiber density (CNFD) compared to healthy individuals, indicating nerve damage associated with the disease.
Article Abstract
Parkinson's disease (PD) is a chronic, progressive neurodegenerative disease affecting about 2-3% of population above the age of 65. In recent years, Parkinson's research has mainly focused on motor and non-motor symptoms while there are limited studies on neurodegeneration which is associated with balance problems and increased incidence of falls. Corneal confocal microscopy (CCM) is a real-time, non-invasive, in vivo ophthalmic imaging technique for quantifying nerve damage in peripheral neuropathies and central neurodegenerative disorders. CCM has shown significantly lower corneal nerve fiber density (CNFD) in patients with PD compared to healthy controls. Reduced CNFD is associated with decreased intraepidermal nerve fiber density in PD. This review provides an overview of the ability of CCM to detect nerve damage associated with PD.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330988 | PMC |
| http://dx.doi.org/10.1186/s40035-020-00204-3 | DOI Listing |
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