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MHC Class I-Restricted TCR-Transgenic CD4 T Cells Against STEAP1 Mediate Local Tumor Control of Ewing Sarcoma In Vivo. | LitMetric
In this study we report the functional comparison of T cell receptor (TCR)-engineered major histocompatibility complex (MHC) class I-restricted CD4 versus CD8 T cells targeting a peptide from (STEAP1) in the context of HLA-A*02:01. STEAP1 is a tumor-associated antigen, which is overexpressed in many cancers, including Ewing sarcoma (EwS). Based on previous observations, we postulated strong antitumor potential of tumor-redirected CD4 T cells transduced with an HLA class I-restricted TCR against a STEAP1-derived peptide. We compared CD4 T cell populations to their CD8 counterparts in vitro using impedance-based xCELLigence and cytokine/granzyme release assays. We further compared antitumor activity of STEAP-TCR transgenic (tg) CD4 versus CD8 T cells in tumor-bearing xenografted Rag2gc mice. TCR tgCD4 T cells showed increased cytotoxic features over time with similar functional avidity compared to tgCD8 cells after 5-6 weeks of culture. In vivo, local tumor control was equal. Assessing metastatic organotropism of intraveniously (i.v.) injected tumors, only tgCD8 cells were associated with reduced metastases. In this analysis, EwS-redirected tgCD4 T cells contribute to local tumor control, but fail to control metastatic outgrowth in a model of xenografted EwS.
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