[This corrects the article DOI: 10.1371/journal.pone.0170591.].
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329070 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235729 | PLOS |
Shortly after serum-deprived BALB/c 3T3 fibroblasts are stimulated to grow in medium containing 10% calf serum, the RNA polymerase I activity in permeabilized cells shows a two-fold increase over the values observed in either serum-deprived or density-inhibited resting cells. Inhibition of protein synthesis by pactamycin or cycloheximide specifically reduces the enhanced RNA polymerase I activity in serum-stimulated cultures without affecting the values in resting cells. On the other hand, inhibition of rRNA processing by the nucleoside analogs 5-fluoruridine and toyocamycin decreases the rate of 45S rRNA transcription in serum-stimulated cells but has no effect on the values found in resting cultures.
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