The 10-Year Prognosis and Prevalence of Brugada-Type Electrocardiograms in Elderly Women: A Longitudinal Nationwide Community-Based Prospective Study.

J Cardiovasc Nurs

Sherri Shih-Fan Yeh, MD Attending physician, Department of Environmental and Occupational Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan. Ching-Yu Julius Chen, MD Attending physician, Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. I-Chien Wu, MD, PhD Assistant investigator, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. Chih-Cheng Hsu, MD, PhD Deputy director, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. Tzu-Yu Chen, PhD Postdoctoral researcher, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. Wei-Ting Tseng, PhD Postdoctoral researcher, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. Feng-Cheng Tang, MD, PhD Associate professor, Department of Occupational Medicine, Changhua Christian Hospital, Changhua, Taiwan Chi-Chung Wang, MD, PhD Attending physician, Department of Family Medicine, Mennonite Christian Hospital, Hualien, Taiwan. Chung-Chou Juan, MD, PhD Associate professor, Department of Surgery, Yuan's General Hospital, Kaohsiung, Taiwan. Hou-Chang Chiu, MD, PhD Professor, Department of Neurology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, and College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan. Huey-Ming Lo, MD, PhD Professor, Section of cardiology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, and School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan. Dun-Hui Yang, MD Attending physician, Department of Radiology, Tainan Municipal Hospital, Tainan, Taiwan. Jyh-Ming Jimmy Juang, MD, PhD Associate professor, Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Chao Agnes Hsiung, PhD Director, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.

Published: October 2021

AI Article Synopsis

  • Brugada syndrome is linked to sudden cardiac death and characterized by abnormal ECG results, but research mainly focused on men, particularly lacking in data about elderly women.
  • A study analyzed the 10-year prognosis of Brugada ECG patterns in women over 55 in Taiwan, revealing that 2.31% had Brugada-type ECGs, which is higher than the global average.
  • Results showed no significant differences in all-cause or cardiac mortality between women with Brugada-type ECGs and those without, suggesting these patterns may not pose an increased long-term mortality risk.

Article Abstract

Background: Brugada syndrome is a disorder associated with sudden cardiac death and characterized by an abnormal electrocardiogram (ECG). Previous studies were predominantly conducted in men, and the data on long-term prognosis are limited. Information about women, especially elderly women, is lacking.

Objective: The aim of this study was to investigate the long-term prognosis of the Brugada ECG pattern in elderly women.

Method: We investigated the 10-year prognosis of the Brugada ECG pattern in elderly women in a nationwide community-based population in Taiwan. Community-dwelling women older than 55 years were prospectively recruited from December 2008 to March 2013 by a stratified random sampling method. All enrolled individuals were followed up annually until April 2019, and the cause of death was documented by citizen death records.

Results: Among 2597 women, 60 (2.31%) had a Brugada-type ECG, and this prevalence was higher than the mean global prevalence of 0.23%. One woman had a type 1 ECG (0.04%), whereas 15 (0.58%) and 44 (1.70%) women had type 2 and type 3 ECG patterns, respectively. Cox survival analysis revealed that all-cause mortality and cardiac mortality were similar in the individuals with and without a Brugada-type ECG during a mean follow-up of 96.1 ± 20.5 months.

Conclusions: Our findings suggest that Brugada ECG patterns are not infrequent in elderly women but are not associated with increased risk of mortality in long-term follow-up; these findings may help reduce unnecessary anxiety for physicians, nurses, allied health caregivers, and patients.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553189PMC
http://dx.doi.org/10.1097/JCN.0000000000000722DOI Listing

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