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In this article, the results of a research project on the objective oral health of Parkinson's disease patients, related to the duration and the progression of the disease, are reported. Participants were 74 patients with Parkinson's disease and 74 control persons. All participants were orally examined. Dentate Parkinson's disease patients had statistically significantly more teeth with carious lesions, more tooth root remnants, and more biofilm and food particles when compared to dentate control persons. Within the group of dentate Parkinson's disease patients, the number of teeth with restorations as well as the number of mobile teeth were positively related to the duration of the disease. Additionally, in this group the number of teeth with carious lesions, the number of teeth with restorations, and the number of tooth root remnants were positively related to the progression of the disease. Parkinson's disease patients need daily oral hygiene care support, particularly in advanced stages of the disease.
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http://dx.doi.org/10.5177/ntvt.2020.05.19131 | DOI Listing |
J Voice
March 2025
Graduate Program in Human Communication Health, Health Sciences Center, Speech-Language Pathology and Audiology Department, Federal University of Pernambuco, Recife, Brazil. Electronic address:
Objective: To compare the post technique effect of pushing with plosive sounds associated with virtual reality (VR) using electromyographic biofeedback and rhythmic auditory stimulation (RAS) on acoustic parameters in the voice of individuals with Parkinson's disease (PD).
Method: The study sample included 30 individuals with PD (15 men and 15 women), with a mean age of 62.13 ± 9.
Neurobiol Dis
March 2025
Department of Psychiatry and Neurosciences, Université Laval, 1050 Av. de la Médecine, Québec G1V 0A6, Québec, Canada; Integrative Neuroscience and Experimental Therapies Axis, CERVO Brain Research Center, 2301 Av. D'Estimauville, Québec G1E 1T2, Québec, Canada. Electronic address:
Background: Parkinson's disease is typically diagnosed after substantial neurodegeneration despite early non-motor symptoms manifesting decades earlier. These changes offer a promising avenue for diagnostic exploration, especially within the eye, which has been proposed as a "window to the brain."
Objective: The aim was to identify biomarkers by validating the use of electroretinography, a non-invasive technique, to detect early retinal function anomalies reflecting central dysfunction.
Brain Res
March 2025
Chitkara College of Pharmacy, Chitkara University, Punjab, India. Electronic address:
Synucleinopathies and amyloidogenic disorders are the two most prevalent neurodegenerative conditions, characterized by progressive loss of neurons and aggregation of proteins in the central nervous system. Emerging evidence suggests that despite their distinct pathological hallmarks: α-synuclein in Parkinson's disease (PD) and amyloid-β in Alzheimer's disease (AD), both disorders share common molecular pathways, including oxidative stress, neuroinflammation, misfolding/aggregation of proteins and mitochondrial dysfunction. This review explores the molecular intersections between synucleinopathies and amyloidogenesis.
View Article and Find Full Text PDFJ Mov Disord
March 2025
Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Objective: Mobility limitations and falls are common in people with Parkinson's disease (PwP). A tailored, multidomain intervention has the potential to be more effective in improving mobility safety and preventing falls than exercise alone. This study aimed to explore the feasibility and potential effectiveness of a multidomain fall prevention intervention (Integrate) designed for PwP who fall frequently.
View Article and Find Full Text PDFEur J Med Chem
March 2025
Department of Bioscience & Bioengineering, Indian Institute of Technology, Jodhpur, Rajasthan, 342037, India. Electronic address:
Parkinson's disease (PD) is a common neurodegenerative disease affecting motor and non-motor functions, with no effective treatment yet discovered. Neuroprotective compounds, both natural and synthetic, show promise but face challenges such as crossing the blood-brain barrier, limited serum stability, and higher toxicity. To tackle these obstacles, we have devised an innovative design strategy inspired by the neuroprotective properties of Leonurine, widely utilized in managing neurological disorders.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!