[Lymphokine-like activity in a culture of cells of the embryonal human brain and in the cerebrospinal fluid].

Factors functionally similar or even identical to interleukin-1 (IL-1) and interleukin-2 (IL-2) were found in the tissues of human embryo. These factors were found to be in reciprocal interrelationship. No activity of colony-stimulating factor was found in materials of cerebral origin. A high level of activity of the IL-2 was observed in the CSF of epileptic patients. The data obtained suggest a participation of lymphokines in the mechanisms of cellular cooperation in the brain as well as in proliferative processes underlying progressing diseases of the central nervous system.