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Orofacial Manifestation of Systemic Sclerosis: A Cross-Sectional Study and Future Prospects of Oral Capillaroscopy.
Diagnostics (Basel)
February 2024
Complex Operative Unit of Odontostomatology, Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Article Synopsis
- The study focuses on the oral health challenges faced by patients with Systemic Sclerosis (SSc), highlighting issues such as dryness, gum disease, and mouth opening restrictions compared to healthy individuals.
- Researchers utilized various clinical assessments and quality of life surveys to evaluate both SSc patients and healthy controls, finding significant disparities in oral manifestations and overall well-being.
- Results revealed that SSc patients experience more severe oral symptoms and noticeably reduced quality of life, while oral videocapillaroscopy was identified as a valuable tool for detecting microcirculation changes specific to SSc.
Focal Dermal Hypoplasia Associated With Lymphedema: A Case Report From Saudi Arabia.
Cureus
April 2023
Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, SAU.
Article Synopsis
- Focal dermal hypoplasia (FDH), or Goltz syndrome, presents mainly with patchy skin hypoplasia, and can also involve hyperpigmentation, limb defects, and oral health issues, with a 12-year-old Saudi girl being a recent case study.
- Diagnosis of FDH was confirmed through genetic testing, and physical examination revealed significant skin abnormalities along Blashko lines without any mental impairment.
- The syndrome shows considerable variability in symptoms among patients, necessitating individualized management strategies and highlighting the need for further case reporting to enhance understanding of FDH.
A missense mutation potentially involved in the pathogenesis of hereditary hemorrhagic telangiectasia: a case report.
J Int Med Res
March 2023
Department of Hematology, Southwest Hospital, First Affiliated Hospital of the Army Medical University, Chongqing 400038, China.
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disease. and gene variants account for up to 96% of all cases, while the remaining cases are caused by or variants, or by currently undiscovered mutations in coding or non-coding regions. Here, we report a 47-year-old man who presented with duodenal bulb bleeding and chronic anemia.
View Article and Find Full Text PDFTrichoscopic, oral, and periungual fold findings as activity and damage markers in dermatomyositis patients and their correlation with myositis antibodies.
Arch Dermatol Res
August 2023
Department of Dermatology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Av. Vicuña Mackenna 4686. Macul, 7820436, Santiago, Chile.
There is little clarity about the clinical manifestations of dermatomyositis (DM) in the periungual folds, scalp, and oral cavity and their association with disease activity and damage. The objective of this study was to compare the prevalence of trichoscopic, oral, and periungual changes between DM and healthy patients and assess their possible association with disease activity and damage. We conducted an observational, transversal, and analytical study between 2020 and 2021.
View Article and Find Full Text PDFA phase I/II study of preoperative letrozole, everolimus, and carotuximab in stage 2 and 3 hormone receptor-positive and Her2-negative breast cancer.
Breast Cancer Res Treat
April 2023
University of Alabama at Birmingham, Birmingham, AL, USA.
Purpose: In nonmetastatic hormone receptor-positive and Her2-negative breast cancer, preoperative endocrine therapies can yield outcomes similar with chemotherapy. We evaluated the tolerability and preliminary antitumor activity of preoperative letrozole, everolimus, and carotuximab, a monoclonal antibody targeting endoglin, in nonmetastatic breast cancer.
Methods: Eligible patients had newly diagnosed, stage 2 or 3, hormone receptor-positive and Her2/neu-negative breast cancer.
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