AI Article Synopsis
- The study investigates the connection between sedentary behavior and breast cancer risk, applying dose-response analysis from cohort studies.
- The meta-analysis included data from eight studies with over 17,000 breast cancer cases, revealing a borderline significant link between prolonged sedentary behavior and increased cancer risk.
- It suggests that for every additional hour of sedentary behavior or TV viewing, there is a corresponding increase in breast cancer risk, particularly noted in Asian countries at 21.6% and 8.26% in North America.
Article Abstract
Background: Emerging studies examined the association between sedentary behavior and risk of breast cancer, however, the dose-response relationship remained unclear. We aim to explore dose-response relationship of sedentary behavior and breast cancer risk based on relevant cohort studies.
Methods: Online database (PubMed, Web of Science, EMBASE and Cochrane Library) were searched up to March 29, 2019. Overall relative risk (RR) with 95% confidence interval (CI) were pooled, and generalized least squares (GLS) method and restricted cubic splines were applied to evaluate the linear or nonlinear relation. Attributable risk proportion (ARP) was used to assess the health hazards of sedentary behavior in different countries.
Results: Eight prospective studies were included in the meta-analysis, containing 17 048 breast cancer cases and 426 506 participants. The borderline statistical association was detected between prolonged sedentary behavior and risk of breast cancer (RR 1.08, 95% CI 0.99-1.19). Linear association between sedentary and breast cancer was observed (P = 0.262), and for 1 h/d increment of sedentary behavior, there was 1% increase of breast cancer risk (RR 1.01, 95% CI1.00-1.02). Similar results were also found between TV viewing and risk of breast cancer (P = 0.551), with 1 h/day increment of TV viewing daily attributing to 2% increase of breast cancer risk (RR 1.02, 95% CI 1.00-1.04). Moreover, sedentary behavior may statistically increase the risk of breast cancer by 21.6% for Asian countries, 8.26% for North America.
Conclusions: Sedentary behavior was validated as a risk factor of breast cancer through dose-response analysis, especially TV viewing.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12282-020-01126-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!