Background: Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system associated with a variety of symptoms and functional deficits. Balance impairment is a common concern in patients with MS. Core muscle stabilization is considered a main component of balance. The strength and endurance of core muscles have not been compared between patients with MS and healthy people. The objective of this study was to compare core muscle strength and endurance between ambulatory patients with MS and a healthy group.
Methods: Thirty-three patients with MS with Expanded Disability Status Scale scores ranging from 1.0 to 4.5 and 33 matched healthy people participated in this cross-sectional group comparison study. The primary outcome measure was endurance of core muscles assessed by functional endurance tests, and the secondary outcome was isometric strength of core muscles assessed using a dynamometer.
Results: Patients with MS had lower performance on endurance tests (P < .001) and strength tests (P < .05) compared with the control group.
Conclusions: These results show decreased core muscle strength and endurance in ambulatory individuals with MS compared with a matched control group. Future studies are required to assess how core muscle impairment affects balance and how it would be affected by rehabilitation and exercise programs.
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http://dx.doi.org/10.7224/1537-2073.2015-064 | DOI Listing |
Eur Geriatr Med
January 2025
Department of Biomedical and Neuromotor Science, Alma Mater Studiorum Università di Bologna, Ravenna Campus, Ravenna, Italy.
Purpose: Sarcopenia is a progressive and generalized skeletal muscle disorder, involving the accelerated loss of skeletal muscle mass and function, associated with an increased probability of adverse outcomes including falls. The circadian timing system may be involved in molecular pathways leading to sarcopenia in older adults. We aimed to provide an updated and systematic map of the available evidence on the role of the circadian timing system in sarcopenia, specifically related to the aging process.
View Article and Find Full Text PDFNat Metab
January 2025
State Key Laboratory of Membrane Biology, MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China.
Exercise can rapidly increase core body temperature, and research has indicated that elevated internal body temperature can independently contribute to fatigue during physical activity. However, the precise mechanisms responsible for regulating thermogenesis in muscles during exercise have remained unclear. Here, we demonstrate that cellular Feimin (cFeimin) enhances exercise performance by inhibiting muscle thermogenesis during physical activity.
View Article and Find Full Text PDFNat Commun
January 2025
National Institute for Physiological Sciences, National Institutes of Natural Sciences (NINS), Okazaki, Japan.
The presence of redox-active molecules containing catenated sulfur atoms (supersulfides) in living organisms has led to a review of the concepts of redox biology and its translational strategy. Glutathione (GSH) is the body's primary detoxifier and antioxidant, and its oxidized form (GSSG) has been considered as a marker of oxidative status. However, we report that GSSG, but not reduced GSH, prevents ischemic supersulfide catabolism-associated heart failure in male mice by electrophilic modification of dynamin-related protein (Drp1).
View Article and Find Full Text PDFNat Commun
January 2025
Department of Molecular Physiology of Exercise and Nutrition, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruecke, Nuthetal, Germany.
Metabolic flexibility in skeletal muscle is essential for maintaining healthy glucose and lipid metabolism, and its dysfunction is closely linked to metabolic diseases. Exercise enhances metabolic flexibility, making it an important tool for discovering mechanisms that promote metabolic health. Here we show that pantothenate kinase 4 (PanK4) is a new conserved exercise target with high abundance in muscle.
View Article and Find Full Text PDFDevelopment
January 2025
Department of Zoology, Graduate School of Science, Kyoto University, Sakyo, Kyoto, 606-8502, Japan.
Ascidian larval muscle cells present a classic example of autonomous development. A regulatory mechanism for these cells has been extensively investigated, and the regulatory gene circuit has been documented from maternal factors to a muscle-specific gene. In the present study, we comprehensively identified genes expressed specifically in ascidian muscle cells, and found that all of them are under control of a positive regulatory loop of Tbx6-r.
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