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The course of plasma alpha-1-microglobulin and haemolysis during cardiac surgery and the relationship to acute kidney injury, a pilot study.
Scand J Clin Lab Invest
December 2024
Department of Cardiothoracic Surgery, Anaesthesia, Perfusion, and Intensive Care, Skåne University Hospital, Lund, Sweden.
Haemolysis occurring during cardiac surgery with cardiopulmonary bypass (CPB) is assumed to be a risk factor for postoperative acute kidney injury (AKI). Plasma alpha-1 microglobulin (A1M) may have a protective role as haem scavenger. The aim of this study was to evaluate the association between AKI and the degree of haemolysis and the course of A1M concentrations during cardiac surgery, respectively.
View Article and Find Full Text PDFIntegrated Profiling of Extracellular Vesicle microRNA Impact on Trabecular Meshwork mRNA Expression: Insights From Microarray Analysis.
Invest Ophthalmol Vis Sci
December 2024
Department of Software and Information Systems Engineering, Faculty of Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Purpose: Extracellular vesicles (EVs) secreted by non-pigmented ciliary epithelial (NPCE) cells under oxidative stress may contribute to primary open-angle glaucoma (POAG) pathogenesis by altering gene expression in human trabecular meshwork (HTM) cells. This study investigated the impact of microRNAs (miRNAs) carried by NPCE-derived EVs on HTM cell gene expression under oxidative stress conditions.
Methods: NPCE cells were exposed to oxidative stress, and EVs were isolated from control and stressed cells.
Retinal Docosahexaenoic Acid Is Significantly Reduced in Diabetic Humans and Mice: Possible Relationship to Diabetic Retinopathy.
Invest Ophthalmol Vis Sci
December 2024
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States.
Purpose: The retina contains the highest concentration of the omega 3 fatty acid, docosahexaenoic acid (DHA), in the body. Although epidemiologic studies showed an inverse correlation between the consumption of omega 3 fatty acids and the prevalence of diabetic retinopathy, there are no data showing the effect of diabetes on retinal DHA in humans. In this study, we measured the DHA content of the retina in diabetic and non-diabetic humans as well as mice and determined the effect of diabetes on retinal thickness and function in mice.
View Article and Find Full Text PDFNavigating the Institutional Review Board and other institutional entities: An ode to aspiring YPAR scholars.
Am J Community Psychol
December 2024
Institutional Review Board, Boston University, Boston, Massachusetts, USA.
Youth-led participatory action research (YPAR) engages young people as partners in rigorous research inquiry to guide and inform collective action. Scholars interested in YPAR have notable investment in social justice and activist values, which at times come in direct tensions within their doctoral training and/or professional roles within academia. One monumental hurdle in conducting YPAR is obtaining approval from the Institutional Review Board (IRB).
View Article and Find Full Text PDFNitrogen Deposition Weakens Soil Carbon Control of Nitrogen Dynamics Across the Contiguous United States.
Glob Chang Biol
December 2024
Stockbridge School of Agriculture, University of Massachusetts Amherst, Amherst, Massachusetts, USA.
Anthropogenic nitrogen (N) deposition is unequally distributed across space and time, with inputs to terrestrial ecosystems impacted by industry regulations and variations in human activity. Soil carbon (C) content normally controls the fraction of mineralized N that is nitrified (ƒ), affecting N bioavailability for plants and microbes. However, it is unknown whether N deposition has modified the relationships among soil C, net N mineralization, and net nitrification.
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