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Genetic polymorphism in β-site amyloid precursor protein-cleaving enzyme 1 affects the structure of medial temporal lobe and cognition in Alzheimer's disease: an exploratory study.
Eur Arch Psychiatry Clin Neurosci
December 2024
Department of Neurology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, 230022, Anhui, China.
The β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) gene polymorphism (rs638405) has been widely reported to be associated with Alzheimer's disease (AD) risk. However, studies on the relationship between BACE1 gene polymorphism (rs638405), brain volume, and cognition in AD patients remain scarce. To investigate the effect of genetic polymorphism in BACE1 on gray matter volume (GMV) and cognition in AD, this study recruited 111 cognitively unimpaired (CU) controls and 144 AD patients.
View Article and Find Full Text PDFDifferential effects of intrinsic- versus extrinsic-first corrective exercise programs on morphometric outcomes and navicular drop in pediatric flatfoot.
Sci Rep
December 2024
Health and Sports Medicine Department, Faculty of Sports Sciences and Health, University of Tehran, North Karegar St, P.O.B: 1439813117, Tehran, Iran.
Although the connection between muscular strength and flatfoot condition is well-established, the impact of corrective exercises on these muscles remains inadequately explored. This study aimed to assess the impact of intrinsic- versus extrinsic-first corrective exercise programs on muscle morphometry and navicular drop in boys with flexible flatfoot. Twenty-five boys aged 10-12 with flexible flatfoot participated, undergoing a 12-week corrective exercise program, with a shift in focus at six weeks.
View Article and Find Full Text PDFFree medial sural artery perforator flap for soft tissue defects in the hand: a cadaver study.
Hand Surg Rehabil
December 2024
Department of Hand Surgery, Plastic and Reconstructive Surgery, Centre Chirurgical Émile Gallé, Nancy University Hospital, 49 rue Hermite, 54000 Nancy, France; Department of Anatomy, Faculty of Medicine, University of Lorraine, 9 Av. de la Forêt de Haye, 54500 Vandœuvre-lès-Nancy, France. Electronic address:
We carried out a cadaver study using 10 fresh-frozen adult legs and hands to explore technical feasibility and reproducibility of the free Medial Sural Artery Perforator flap and its applicability for covering soft tissue defects in the hand. A mean of 2 cutaneous perforators (1-4) were found. Each flap had a pedicle composed of a main perforator that arose from the medial sural artery.
View Article and Find Full Text PDFSex Differences in Spatiotemporal Consistency and Effective Connectivity of the Precuneus in Autism Spectrum Disorder.
J Autism Dev Disord
December 2024
School of Information Science and Engineering, Yanshan University, Qinhuangdao, 066004, China.
Autism spectrum disorder (ASD) has been reported to exhibit altered local functional consistency. However, previous studies mainly focused on male samples and explored the temporal consistency in the ASD brain ignoring the spatial consistency. In this study, FOur-dimensional Consistency of local neural Activities (FOCA) analysis was used to investigate the sex differences of local spatiotemporal consistency of spontaneous brain activity in ASD.
View Article and Find Full Text PDF[The relationship between neuropsychological indicators and neuroimaging changes according to MRI morphometry in patients with Alzheimer's disease and glaucoma].
Zh Nevrol Psikhiatr Im S S Korsakova
December 2024
Federal Center of Brain Research and Neurotechnologies, Moscow, Russia.
Objective: Study of neuroimaging changes according to MRI morphometry and their comparison with the structure and severity of cognitive impairment (CI) in patients with Alzheimer's disease (AD) and primary open-angle glaucoma (POAG).
Material And Methods: The study involved 90 patients who were divided into two equal groups of 45 people and who early had diagnosis of AD (group 1; median age - 71 [66; 77] years) and POAG (group 2; median age - 68 [64; 77] years). 71] years).
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