Background: The Jat Sikh population is the largest endogamous group of Punjab, a state in north-west India, and has not yet been explored for genetic polymorphism based on X-STR genetic markers. In India, which is the second most populous country in the world, only two population studies based on X-STR markers have been reported so far.
Aim: To explore the genetic diversity of 12 X chromosomal STR genetic markers in the Jat Sikh population of Punjab and expand the X-STR polymorphism database.
Subjects And Methods: In this study, a total of 200 Jat Sikh individuals (100 males and 100 females) residing in Punjab were investigated for 12 X-STR markers using the Investigator Argus X-12 QS Kit.
Results: The highest power of discrimination (PD) in females (PD) and males (PD) was observed to be 0.965 (DXS10135) and 0.929 (DXS10135 and DXS10148), respectively. DXS10135 was found to be the most polymorphic and discriminating locus among all the studied loci in both males and females with highest values of power of discrimination (PD) and polymorphic information content (PIC) as well.
Conclusion: Overall, the studied markers of the Argus 12 X-STR kit provide high polymorphic information which may prove to be an important tool in resolving issues such as missing person identification, incest, immigration disputes, kinship analysis and genealogical studies. The dataset obtained from this study will add to the present database of X-STRs.
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http://dx.doi.org/10.1080/03014460.2020.1772876 | DOI Listing |
Int J Mol Sci
August 2024
Department of Human Genetics, Punjabi University, Patiala 147002, India.
Ann Hum Biol
February 2022
DNA Fingerprinting Unit, State Forensic Science Laboratory, Department of Home (Police), Government of Madhya Pradesh, Sagar, Madhya Pradesh, India.
Aim: The present study was designed to explore the STR diversity and genomic history of the inhabitants of the most populous subdivision of the country. A set of 24 hypervariable autosomal STRs was used to estimate the genetic diversity within the studied population. A panel of 15 autosomal STRs, which is most common in the previously reported data sets, was used to estimate the genetic diversity between the studied population, and obtained unique relations were reported here.
View Article and Find Full Text PDFAnn Hum Biol
August 2020
DNA Division, State Forensic Science Laboratory, Jaipur, India.
Ann Hum Biol
August 2020
Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India.
Background: Autosomal STR typing using capillary electrophoresis is a reliable method for establishing parentage and for deciphering genomic ancestry.
Aim: This study was planned to show the genetic diversity of the Jat Sikh population, which is a widespread community of the Punjab region, and to assess its genetic relationship with existing Indian populations.
Subjects And Methods: Blood samples of unrelated healthy individuals of the Jat Sikhs (n = 123) were used in this study.
Int J Legal Med
September 2020
Department of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab, India.
In the present study, allele frequencies and forensic parameters of four ethnic groups (Brahmin, Khatri, Jat Sikh, and Scheduled Caste) of Punjab, India, at 10 Alu insertions of X chromosome were calculated. Six Alu markers were observed to be highly polymorphic with no significant deviations from Hardy-Weinberg equilibrium and no linkage disequilibrium present in any marker. Multidimensional plot showed higher genetic affinity of studied populations with Asian populations.
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