Childhood pneumonia is a major public health problem. The aim of this prospective hospital-based study is to determine the incidence and risk factors for community-acquired severe pneumonia in children in Ujjain, India. The study includes 270 children, 161 (60%) boys and 109 (40%) girls, aged between 2 months and 5 years with World Health Organization defined and radiologically confirmed severe pneumonia. Considering the 270 children, 64% (95% confidence interval (CI)57.9-69.4) have severe pneumonia. The following are identified as risk factors for severe pneumonia from the generalized logistic regression model: Born premature (adjusted odds ratio (AOR) 7.50; 95% CI 2.22-25.31; = 0.001); history of measles (AOR 6.35; 95% CI 1.73-23.30; = 0.005); incomplete vaccination (AOR 2.66; 95% CI 1.09-6.48; = 0.031); acyanotic congenital heart disease (AOR 9.21; 95% CI 2.29-36.99; = 0.002); home treatment tried (AOR 3.84; 95% CI 1.42-10.39; = 0.008); living in a kuchha house (AOR 3.89; 95% CI 1.51-10.01; = 0.027); overcrowding (AOR 4.50; 95% CI 1.75-11.51; = 0.002);poor ventilation in living area (AOR 16.37; 95% CI 4.67-57.38; < 0.001); and practicing open defecation (AOR 16.92; 95% CI 4.95-57.85; < 0.001). Awareness of these risk factors can reduce mortality due to severe pneumonia.
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http://dx.doi.org/10.3390/ijerph17134637 | DOI Listing |
J Trauma Acute Care Surg
January 2025
From the Department of Surgery, Westchester Medical Center, New York Medical College, Valhalla, NY.
Background: Extracorporeal membrane oxygenation (ECMO) has emerged as a critical intervention in the management of patients with trauma-induced cardiorespiratory failure. This study aims to compare outcomes in patients with severe thoracic injuries with and without venovenous extracorporeal membrane oxygenation (VV-ECMO).
Methods: We performed a retrospective cohort study on Trauma Quality Improvement Program (2017-2021) and included all patients with isolated blunt thoracic injuries with Abbreviated Injury Scale score of ≥4 who required intubation.
Swiss Med Wkly
December 2024
Center for Primary Care and Public Health (Unisanté), Department of Epidemiology and Health Systems, University of Lausanne, Lausanne, Switzerland.
Aim: To assess the perceptions of adults with diabetes regarding their care and health during the COVID-19 pandemic in the canton of Vaud, Switzerland.
Methods: Cross-sectional data was analysed from the 2021 follow-up questionnaire of the CoDiab-VD survey, a cohort of adults living with diabetes in the canton of Vaud. Various aspects of diabetes care and issues relating to the COVID-19 pandemic were assessed.
Geriatr Psychol Neuropsychiatr Vieil
December 2024
Service de médecine gériatrique Charles-Nicolle, CHU, Rouen, France, Unirouen, Inserm U1096, Université Normandie, Rouen, France.
A quarter of nursing home residents dies in hospital. Few data are available about early in-hospital deaths of nursing home residents. The aim of the study was to describe the characteristics of early in-hospital deaths of nursing home residents after an admission in emergency department and to identify factors associated with a decision of limitation of care in emergency department.
View Article and Find Full Text PDFJ Med Virol
January 2025
Department of Anatomy, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an RNA virus responsible for coronavirus disease 2019 (COVID-19). While SARS-CoV-2 primarily targets the lungs and airways, it can also infect other organs, including the central nervous system (CNS). The aim of this study was to investigate whether the choroid plexus could serve as a potential entry site for SARS-CoV-2 into the brain.
View Article and Find Full Text PDFFront Cell Infect Microbiol
January 2025
Center for Infectious Diseases Research (CIDR) and WHO Collaborating Center for Reference and Research on Bacterial Pathogens, American University of Beirut, Beirut, Lebanon.
Introduction: Multidrug resistant Gram-negative bacterial infections are considered a major public health threat. Immunocompromised pediatric patients are at a great risk of severe or overwhelming infections. The aim of this study was to describe the frequency of infections with multidrug resistant (MDR) Gram-negative bacteria (GNB) in immunocompromised pediatric patients and to determine the risk factors.
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