Obstructive Sleep Apnea (OSA) is the most common breathing-related sleep disorder, leading to increased risk of health problems. In this study, we investigated and evaluated the supervised machine learning methods to predict OSA. We used popular machine learning algorithms to develop the prediction models, using a dataset with non-invasive features containing 231 records. Based on the methodology, the CRISP-DM, the dataset was checked and the blanked data were replaced with average/most frequented items. Then, the popular machine learning algorithms were applied for modeling and the 10-fold cross-validation method was used for performance comparison purposes. The dataset has 231 records, of which 152 (65.8%) were diagnosed with OSA. The majority was male (143, 61.9%). The results showed that the best prediction model with an overall AUC reached the Naïve Bayes and Logistic Regression classifier with 0.768 and 0.761, respectively. The SVM with 93.42% sensitivity and the Naïve Bayes of 59.49% specificity can be suitable for screening high-risk people with OSA. The machine learning methods with easily available features had adequate power of discrimination, and physicians can screen high-risk OSA as a supplementary tool.
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http://dx.doi.org/10.3233/SHTI200576 | DOI Listing |
STAR Protoc
December 2024
Princess Máxima Center for Pediatric Oncology, Utrecht 3584 CS, the Netherlands; Oncode Institute, Utrecht 3521 AL, the Netherlands. Electronic address:
The study of somatic mutations in single cells provides insights into aging and carcinogenesis, which is complicated by the dependency on whole-genome amplification (WGA). Here, we describe a detailed workflow starting from single-cell isolation to WGA by primary template-directed amplification (PTA), sequencing, quality control, and downstream analyses. A machine learning approach, the PTA Analysis Toolkit (PTATO), is used to filter the hundreds to thousands of artificial variants induced by WGA from true mutations at high sensitivity and accuracy.
View Article and Find Full Text PDFGut Microbes
December 2025
Hypertension Research Laboratory, School of Biological Sciences, Faculty of Science, Monash, Clayton, Australia.
The gut microbiota is a crucial link between diet and cardiovascular disease (CVD). Using fecal metaproteomics, a method that concurrently captures human gut and microbiome proteins, we determined the crosstalk between gut microbiome, diet, gut health, and CVD. Traditional CVD risk factors (age, BMI, sex, blood pressure) explained < 10% of the proteome variance.
View Article and Find Full Text PDFHum Genomics
December 2024
Precision Medicine Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Background: Atherosclerosis (AS) is a major cause of cardiovascular diseases and neutrophil extracellular traps (NETs) may be actively involved in the development of atherosclerosis. Identifying key biomarkers in this process is essential for developing targeted treatments for AS.
Methods: We performed bioinformatics analysis using a NETosis-related gene (NRGs) set and three AS datasets (GSE100927, GSE21545, and GSE159677).
BMC Pregnancy Childbirth
December 2024
Department of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, 5612 AZ, North Brabant, The Netherlands.
This study aimed to predict preterm birth in nulliparous women using machine learning and easily accessible variables from prenatal visits. Elastic net regularized logistic regression models were developed and evaluated using 5-fold cross-validation on data from 8,830 women in the Nulliparous Pregnancy Outcomes Study: New Mothers-to-Be (nuMoM2b) dataset at three prenatal visits: - , - , and - weeks of gestational age (GA). The models' performance, assessed using Area Under the Curve (AUC), sensitivity, specificity, and accuracy, consistently improved with the incorporation of data from later prenatal visits.
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