The line-edge roughness (LER) is a critical issue that significantly impacts the critical dimension (CD) because the LER does not scale with the feature size. Hence, the LER influences the device performance with 7-nm and 5-nm patterns. In this study, LER impact on the performance of the fin-field-effect-transistors (FinFETs) are investigated using a compact device method. The fin-width roughness (FWR) is based on the stochastic fluctuation such as the LER and the line-width roughness (LWR) in the lithography process. The calculated results of the FWRs and the gate lengths L = 7-nm and 5-nm are addressed with the cases of electric potentials with the -direction along the gate length, electric potentials with the -direction along the fin width, and the absolute drain currents with the gate lengths L = 7-nm or 5-nm due to gate voltages. According to the gate length, the impact of the FWR patterns on the performance of fin-field-effect-transistors (FinFETs) can find regular fluctuations.
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http://dx.doi.org/10.1166/jnn.2020.18814 | DOI Listing |
Recent Pat Biotechnol
January 2025
Professor Biochemistry Division, Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
Background: Trophoblast Cell Surface Antigen 2 (Trop2) is a transmembrane glycoprotein that has been implicated in the progression and metastasis of various cancers, including hepatocellular carcinoma (HCC). Targeting Trop2 expression may represent a promising approach for the development of novel therapeutic strategies.
Objectives: This study aimed to investigate the effects of Trop2 knockdown using small interfering RNA (siRNA) on the phenotypic and molecular characteristics of the HepG2 liver cancer cell line.
Int J Biol Macromol
January 2025
Botany and Microbiology Department, Faculty of Science, Cairo University, Giza 12613, Egypt. Electronic address:
The isolated Aspergillus flavus NSRN22 was used for green synthesis of silver and selenium nanoparticles (AgNPs and SeNPs). New food packaging films produced by combining each type of NPs with chitosan (CS) or sodium alginate (SA) were characterized. Transmission electron microscopy revealed that the average particle size was lower in case of AgNPs (9 to 14.
View Article and Find Full Text PDFJ Med Chem
January 2025
School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China.
The rearranged during transfection (RET) mutation such as the G810C mutation has significantly restricted the clinical application of selective RET inhibitors in the treatment of RET-driven cancers. This study designed and evaluated RET proteolysis targeting chimeras (PROTACs) based on selpercatinib (LOXO-292), identifying as a potent and selective RET PROTAC. effectively inhibited the proliferation of BaF3 cells with various RET mutations, showing IC values of 2.
View Article and Find Full Text PDFPharmaceutics
November 2024
Faculty of Pharmaceutical Science, UNESP-São Paulo State University, Rodovia Araraquara-Jaú, Km 01, Araraquara 14801-902, Brazil.
: This study evaluated how the relative proportion of chitosan (CS) to the polyanions alginate (ALG) and hydroxypropyl-methylcellulose phthalate (HP) affects the colloidal properties of mesalazine (MSZ) nanosuspensions as a strategy to produce particles with specific characteristics. : Nanosuspensions were prepared using a bottom-up approach based on acid-base reactions and were modified with CS in a binary mixture with ALG or a ternary mixture with ALG and HP. The particle size, polydispersity index (PDI), zeta potential, morphology, and drug association efficiency were analyzed.
View Article and Find Full Text PDFPharm Dev Technol
January 2025
Univ Angers, INSERM, CNRS, MINT, SFR ICAT, France.
This work explores two methods to encapsulate Thymoquinone (TQ) into lipid nanocapsules (LNCs) for oral administration. TQ was added during the phase inversion temperature method (TQ-LNCs-1) or to unload LNCs dispersion (TQ-LNCs-2). LNCs were evaluated for mean diameter, polydispersity index (PDI), ζ-potential, drug loading (DL), drop tensiometer, storage stability, stability in simulated gastrointestinal fluids (SGIF), and intestinal permeability across Caco-2 cells.
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