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Vascular Disturbances of the Skin in Critically Ill Patients: Lines, Dots, Patches.
Chest
December 2024
Louisiana State University School of Medicine, New Orleans - Baton Rouge Regional Campus. Electronic address:
When an understanding of pathogenesis exists, skin lesions that have the appearance of blood in the skin can provide insight into the mechanisms leading to a systemic process that results in cutaneous manifestations. Of the vascular disturbances of the skin that occur in critically ill patients, some result from a non-hemorrhagic process while occurs represent bleeding into the skin. The lesions of livedo, petechiae, purpura, and ecchymoses can be approached from such a perspective.
View Article and Find Full Text PDFRhabdomyolysis in Severe Fever With Thrombocytopenia Syndrome: Associations With Acute Kidney Injury and Mortality.
J Med Virol
December 2024
Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, China.
Article Synopsis
- * Among 231 patients, those with rhabdomyolysis experienced more severe symptoms like confusion and pain, and had higher levels of damage markers for various organs compared to those without rhabdomyolysis.
- * Rhabdomyolysis was linked to a lower survival rate and was identified as an independent risk factor for acute kidney injury and death, highlighting the importance of detecting and treating rhabdomyolysis early in SFTS patients.
Health-related quality of life and complications of corticosteroid treatment in patients with immune thrombocytopenia in two teaching hospitals in Ethiopia: a cross-sectional study.
Front Med (Lausanne)
November 2024
Tikur Anbessa Specialized Hospital, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Background: The treatment of immune thrombocytopenia (ITP) is a major clinical challenge and has a significant impact on health-related quality of life (HRQoL), and prolonged use of corticosteroids may have a negative impact on HRQoL.
Objectives: To evaluate the impact of ITP on HRQoL and complications of corticosteroid treatment in patients with ITP in two teaching hospitals in Ethiopia.
Methods: The institution-based cross-sectional study was conducted from November 15, 2022, to March 15, 2023, to recruit 214 study participants during the study period (4 months).
Fanconi anemia (FA) is a rare inherited disorder characterized by congenital abnormalities, progressive bone marrow failure, and a predisposition to malignancies. Detecting FA can be challenging, as it involves identifying increased chromosomal sensitivity to DNA cross-linking agents and detecting causative genetic variants via genome sequencing. We report two cases of siblings with FA, both confirmed to have the FANCD2 variant through whole-exome sequencing (WES).
View Article and Find Full Text PDFRare fatal case of purpura fulminans due to pneumococcal sepsis in a child, associated with multiorgan failure.
Germs
June 2024
MD, PhD, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, No. 37, Dionisie Lupu Street, 020021 Bucharest, Romania, and National Institute for Infectious Diseases "Prof. Dr. Matei Balş", No. 1 Dr. Calistrat Grozovici street, Bucharest, 021105, Romania.
Introduction: is one of the associated bacteria that can cause the rare but high mortality hematological pathology known as purpura fulminans (PF) in both adults and children. Pediatric patients with PF can progress quickly to sepsis and multiorgan failure, especially immunocompromised individuals and young children. Due to the thrombotic blockage of blood arteries in PF, there is diffuse intravascular thrombosis and hemorrhagic infarction of the skin, which evolves from ecchymosis to skin necrosis, risk of limb sequelae, sepsis and fatality.
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