Dubins tours represent a solution of the Dubins traveling salesman problem (DTSP) that is a variant of the optimization routing problem to determine a curvature-constrained shortest path to visit a set of locations such that the path is feasible for Dubins vehicle, which moves only forward and has a limited turning radius. The DTSP combines the NP-hard combinatorial optimization to determine the optimal sequence of visits to the locations, as in the regular TSP, with the continuous optimization of the heading angles at the locations, where the optimal heading values depend on the sequence of visits and vice versa. We address the computationally challenging DTSP by fast evaluation of the sequence of visits by the proposed windowing surrogate model (WiSM), which estimates the length of the optimal Dubins path connecting a sequence of locations in a Dubins tour. The estimation is sped up by a regression model trained using close to optimum solutions of small Dubins tours that are generalized for large-scale instances of the addressed DTSP utilizing the sliding-window technique and a cache for already computed results. The reported results support that the proposed WiSM enables fast convergence of a relatively simple evolutionary algorithm to high-quality solutions of the DTSP. We show that with an increasing number of locations, our algorithm scales significantly better than other state-of-the-art DTSP solvers.
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http://dx.doi.org/10.1109/TCYB.2020.3000465 | DOI Listing |
Sci Rep
January 2025
School of Earth and Environmental Sciences, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, UK.
Dienia is a small, pantropical genus of epidendroid Malaxideae orchids. The floral lip is upwardly directed and does not serve as a landing platform for pollinators. This role has been assumed by sepals and/or gynostemium or whole inflorescence.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Background: "SuperAgers" are older adults (ages 80+) whose cognitive performance resembles that of adults in their 50s to mid-60s. Factors underlying their exemplary aging are underexplored in large, racially diverse cohorts. Using eight cohorts, we investigated the frequency of APOE genotypes in SuperAgers compared to middle-aged and older adults.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Massachusetts Chan Medical School, Worcester, MA, USA.
Background: Several studies have found that oral and gut microbiome and their byproducts can impact Alzheimer's Disease (AD). The objective of our study is to analyze metagenomic sequencing data from paired oral and fecal microbiomes, along with clinical variables, to identify communities of bacteria associated with AD. This research aims to improve our understanding of the microbiome community matrix, and how these communities interact and correlate with AD status compared to healthy controls (HC) through an oral-gut microbial axis.
View Article and Find Full Text PDFBackground: Predicting decline over the course of Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD), especially on relatively short time frames, is vital for appropriate treatment planning and to tailor patient and support systems' expectations. The current study tested if a functional upper limb motor learning task could predict one-year change in cognition and daily function.
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Alzheimers Dement
December 2024
University of Miami Miller School of Medicine, Boca Raton, FL, USA.
Background: When performing a picture description task, healthy individuals tend to look only briefly at a target before beginning its description, after which they move promptly onto the next target. This sequence may be disrupted in those with cognitive impairment. Just as cognitively impaired individuals produce greater numbers of disfluencies and pauses, those with mild cognitive impairment (MCI) may delay speech production by extending their gaze behavior towards a target before beginning its description.
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