The catalytic asymmetric Mannich-type reaction of 3-hydroxy/3-aminooxindoles with 2-aminoacrylates to afford oxindole-derived acyclic amino acid derivatives bearing vicinal tetrasubstituted stereocenters is reported. (DHQ)PHAL () and quinine-derived squaramide () were identified as efficient catalysts. Transformations of the Mannich-type reaction products highlight the utility of this synthetic strategy.
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| http://dx.doi.org/10.1021/acs.joc.0c00981 | DOI Listing |
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