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Expression Profile of Thymidine Kinase Genes in Cervical Squamous Cell Carcinoma Confirmed by Various Detection Methods.
World J Oncol
February 2025
The First Clinical Medical School, Jinan University, Guangzhou 510632, Guangdong, China.
Background: Thymidine kinases (TKs) are key enzymes involved in DNA synthesis and repair, with alterations in their expression associated with various cancers. Thymidine kinase 1 (TK1) and TK2 are cytosolic enzyme proteins that catalyze the addition of a gamma-phosphate group to thymidine. The existing literature on TK1 in cervical squamous cell carcinoma (CESC) fails to address the clinical role of TK1 overexpression and its possible molecular mechanism in CESC.
View Article and Find Full Text PDFDeveloping a comprehensive inventory to define harm reduction housing.
Harm Reduct J
January 2025
Opioid Policy Research Collaborative, Heller School for Social Policy & Management, Brandeis University, Waltham, MA, USA.
Background: The City of Boston has faced unprecedented challenges with substance use amidst changes to the illicit drug supply and increased visibility of homelessness. Among its responses, Boston developed six low threshold harm reduction housing (HRH) sites geared towards supporting the housing needs of people who use drugs (PWUD) and addressing health and safety concerns around geographically concentrated tent encampments. HRH sites are transitional supportive housing that adhere to a "housing first" approach where abstinence is not required and harm reduction services and supports are co-located.
View Article and Find Full Text PDFEnhancing the performance of polyfarnesene-based bio-rubbers with surface-modified cellulose nanocrystals and nanofibers.
Sci Rep
January 2025
Research Center for Applied Chemistry, Blvd Enrique Reyna 140, San José de los Cerritos, Saltillo, 25294, Mexico.
As the rubber industry seeks sustainable alternatives to mitigate its environmental impact, this study introduces a biobased approach using polyfarnesene rubber reinforced with plasma-modified cellulose nanocrystals (MCNC) and nanofibers (MCNF). The nanocellulose was modified by plasma-induced polymerization using trans-β-farnesene and was characterized by FTIR, XPS, XRD, TGA, and SEM to confirm the grafting of farnesene-derived polymer chains onto the cellulose surface, demonstrating the successful modification and integration of the nanoparticles. Polyfarnesene bio-based rubbers were synthesized through two different polymerization techniques: solution-based coordination polymerization (PFA1) and emulsion-based free radical polymerization (PFA2).
View Article and Find Full Text PDFIn vitro comparison of cerumenolytic efficacy: 2.5 % sodium bicarbonate versus 0.5 % sodium docusate based on cerumen weight gain.
Am J Otolaryngol
January 2025
Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Objective: This study aimed to compare the cerumenolytic efficacy of 2.5 % sodium bicarbonate prepared in-house with that of commercially available 0.5 % sodium docusate, utilizing cerumen weight gain and disintegration degree as metrics.
View Article and Find Full Text PDFOpportunities for More Tailored Approaches to Genotoxicity Testing and Carcinogenicity Strategy for Oligonucleotide Therapeutics: Outcome of an Industry Survey.
Nucleic Acid Ther
January 2025
Global Preclinical Safety, AbbVie Inc., North Chicago, Illinois, USA.
The Oligonucleotide Nonclinical Working Group (WG) of the European Federation of Pharmaceutical Industries and Associations conducted an industry survey to understand current practices and regulatory expectations for genotoxicity and carcinogenicity assessment of oligonucleotide therapeutics (ONTs), along with historical genotoxicity testing results. The survey, involving 29 pharmaceutical and biotechnology companies, revealed a consistent absence of genotoxicity across a diverse range of oligonucleotide classes and chemistries, consistent with previous observations. Despite the lack of genotoxicity, companies continue to follow standard testing guidelines, with only limited divergence.
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