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| http://dx.doi.org/10.1111/add.15173 | DOI Listing |
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Postmortem distribution of mitragynine and 7-hydroxymitragynine in 51 cases.
J Anal Toxicol
December 2024
Tarrant County Medical Examiner's Office, Fort Worth, TX 76104, United States.
The prevalence of mitragynine (kratom) in forensic toxicology casework has steadily increased over time. Readily available and currently legal, mitragynine is widely used for its stimulant and, depending on concentration, sedative effects. Our laboratory analyzed various fluid and tissue specimens from 51 postmortem cases to investigate the distribution of mitragynine and its active metabolite 7-hydroxymitragynine.
View Article and Find Full Text PDFThe neuropharmacology of kratom, a novel psychoactive natural product.
Prog Neuropsychopharmacol Biol Psychiatry
December 2024
College of Pharmacy, Department of Pharmaceutical Sciences, Midwestern University, Glendale, AZ, United States; College of Pharmacy, Department of Medicinal Chemistry, University of Florida, Gainesville, FL, United States. Electronic address:
Kratom (Mitragyna speciosa, Korth.) is a tropical tree that is indigenous to Southeast Asia. When ingested, kratom leaves or decoctions from the leaves have been reported to produce complex stimulant and opioid-like effects.
View Article and Find Full Text PDFThe rise of novel, semi-synthetic 7-hydroxymitragnine products.
Addiction
February 2025
Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Kratom Alkaloids for the Treatment of Alcohol Use Disorder.
ACS Chem Neurosci
December 2024
Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77204, United States.
Article Synopsis
- Alcohol use disorder (AUD) leads to significant mortality and economic costs, with limited FDA/EMA-approved treatments available, many of which have adverse effects.
- Kratom alkaloids show promise in reducing alcohol intake and withdrawal symptoms in animal studies by acting on specific opioid receptors.
- The article reviews recent preclinical studies on kratom for AUD treatment, discusses approved and repurposed drugs, and outlines caveats and future research needs.
Enhancing drug-target interaction predictions in context of neurodegenerative diseases using bidirectional long short-term memory in male Swiss albino mice pharmaco-EEG analysis.
Heliyon
November 2024
Healthcare Sensing Technology, Faculty Research Centre for Intelligent Healthcare, Coventry University, Coventry, United Kingdom.
Article Synopsis
- The study focuses on improving the understanding and classification of psychotropic medications' effects on brain activity, particularly for treatments related to neurodegenerative diseases like Parkinson's and Alzheimer's.
- Researchers utilize advanced neural network models, specifically Convolutional Neural Networks and Bidirectional Long Short-Term Memory (LSTM) models, to analyze Pharmaco-EEG recordings and enhance drug classification accuracy.
- Results show promising performance metrics, with most drugs achieving high F1-Scores, particularly morphine, ephedrine, and fluoxetine, indicating the effectiveness of these models in predicting drug classes based on brain bioelectric signals.
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