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Hypertension-induced heart failure disrupts cardiac sympathetic innervation.
Am J Physiol Heart Circ Physiol
December 2024
Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon, United States.
About 26 million people worldwide live with heart failure (HF), and hypertension is the primary cause in 25% of these cases. Autonomic dysfunction and sympathetic hyperactivity accompany cardiovascular diseases, including HF. However, changes in cardiac sympathetic innervation in HF are not well understood.
View Article and Find Full Text PDFEndocardial ablation of ganglionated plexus for the treatment of carotid sinus syndrome.
J Cardiovasc Electrophysiol
January 2025
Arrythmias Unit, University Hospital of Santiago de Compostela, Santiago, Spain.
Article Synopsis
- Carotid sinus syndrome (CSS) leads to severe vagal responses and often requires pacemaker implantation, but this study explores cardioneuroablation (CNA) as a potential alternative treatment.
- The study included 13 patients who underwent various tests before and after the CNA procedure, aiming for no cardioinhibitory response post-treatment and analyzing quality of life improvements.
- Results showed that, after CNA, all but one patient had a negative response to carotid sinus massage, with 84.6% remaining free from syncope and no one needing a pacemaker, indicating CNA may effectively reduce syncopal episodes in CSS patients.
Mechanisms of Vein of Marshall-Related Tachyarrhythmias and the Impact of Ethanol Infusion.
Rev Cardiovasc Med
April 2024
Department of Cardiac Pacing and Electrophysiology, Bordeaux University Hospital (CHU), 33000 Bordeaux, France.
The Ligament of Marshall (LOM) is a remnant of the embryonic sinus venosus and the left cardinal vein, containing a combination of fat, fibrous tissue, blood vessels, muscle bundles, nerve fibers, and ganglia. Various muscular connections exist between the LOM and the left atrium (LA) and the coronary sinus (CS). The LOM is richly innervated by autonomic nerves, with ganglion cells distributed around it.
View Article and Find Full Text PDFImpact of Ethanol Infusion to the Vein of Marshall in Atrial Fibrillation and Atrial Tachycardia.
J Cardiovasc Dev Dis
June 2024
Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
The ligament of Marshall is an epicardial structure characterized by its composition of fat, fibrous tissue, blood vessels, muscle bundles, nerve fibers, and ganglia. Its intricate network forms muscular connections with the coronary sinus and left atrium, alongside adjacent autonomic nerves and ganglion cells. This complexity plays a pivotal role in initiating focal electrical activities and sustaining micro- and macro-reentrant circuits, thereby contributing to the onset of atrial fibrillation and atrial tachycardia.
View Article and Find Full Text PDFComparing pulsed field electroporation and radiofrequency ablation for the treatment of paroxysmal atrial fibrillation: design and rationale of the BEAT PAROX-AF randomized clinical trial.
Europace
May 2024
IHU LIRYC, University Bordeaux, CHU Bordeaux, Bordeaux, France.
Article Synopsis
- The BEAT PAROX-AF trial is a European study comparing pulsed field ablation (PFA) with radiofrequency (RF) ablation for treating drug-resistant paroxysmal atrial fibrillation (AF), focusing on efficacy and safety.
- A total of 292 participants were randomly assigned to either PFA or RF using specific protocols to measure outcomes such as the recurrence of atrial arrhythmia and serious adverse events.
- The study began in December 2021 and will conclude recruitment in January 2024, with results expected to be published in mid-2025, aiming to improve treatment strategies for patients with paroxysmal AF.
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