Tetrahymena is a single-cell eukaryotic organism present in all aquatic environments and can easily be maintained in laboratory conditions in a cost-effective manner. This review gives a brief description of the physiology of Tetrahymena, culture handling, and maintenance of Tetrahymena species. The review article focuses on various toxicological bioassays at different biological organizational (biochemical, individual, population, and community) levels. Furthermore, some techniques such as single cell gel electrophoresis (SCGE) and microcalorimetry assay are also available to investigate the effect of xenobiotics on the integrity of DNA and metabolic state of Tetrahymena species respectively. The article also discusses how the general physiology, behavioural activities and different organelles of Tetrahymena could be useful in toxicological studies. The strength and limitations of Tetrahymena over other model organisms are also discussed. This article also provides suggestions to overcome some problems related to toxicity assessment. Various aspects associated with variability in results, toxicity endpoints, characteristics of organisms and responses against xenobiotic substances (old and new emerging toxicants) are considered.
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