Background And Objective: High-quality vascular modeling is crucial for blood flow simulations, i.e., computational fluid dynamics (CFD). As without an accurate geometric representation of the smooth vascular surface, it is impossible to make meaningful blood flow simulations. The purpose of this work is to develop high-quality vascular modeling and modification method for blood flow computations.
Methods: We develop a new technique for the accurate geometric modeling and modification of vasculatures using implicit extrusion surfaces (IES). In the proposed method, the skeleton of the vascular structure is subdivided into short curve segments, each of which is then represented implicitly locally as the intersection of two mutually orthogonal implicit surfaces defined by distance functions. A set of contour points is extracted and fitted with an implicit curve for accurately specifying the vessel cross-section profile, which is then extruded locally along the skeleton to fill the gaps between two vascular tube cross sections. We also present a new implicit geometric editing technique to modify the constructed vascular model with pathology for virtual stenting.
Results: Experimental results and validations show that accurate vascular models with highly smooth surfaces can be generated by the proposed method. In addition, we conduct some blood flow simulations to indicate the effectiveness of proposed method for hemodynamic simulations.
Conclusions: The proposed technique can achieve precise geometric models of vasculatures with any required degree of smoothness for reliable blood flow simulations.
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http://dx.doi.org/10.1016/j.cmpb.2020.105598 | DOI Listing |
Shock
January 2025
Pharmacology, University of Vermont, Burlington, VT.
Objective: Loss of function of the phospholipid scramblase (PLS) TMEM16F results in Scott Syndrome, a hereditary bleeding disorder generally attributed to intrinsic platelet dysfunction. The role of TMEM16F in endothelial cells, however, is not well understood. We sought to test the hypothesis that endothelial TMEM16F contributes to hemostasis by measuring bleeding time and venous clotting in endothelial-specific knockout (ECKO) mice.
View Article and Find Full Text PDFActa Bioeng Biomech
June 2024
1Department of Biomedical Engineering, Hefei University of Technology, Hefei, People's Republic of China.
: The utilization of intra-aortic balloon pump (IABP) and Impella has been suggested as means of left ventricular unloading in veno-arterial extracorporeal membrane oxygenation (VA-ECMO) patients. This study aimed to assess the local hemodynamic alterations in VA-ECMO patients through simulation analyses. : In this study, a 0D-3D multiscale model was developed, wherein resistance conditions were employed to define the flow-pressure relationship.
View Article and Find Full Text PDFActa Bioeng Biomech
June 2024
4Department of Pediatric Dentistry and Preclinical Dentistry, Wroclaw Medical University, Wrocław, Poland.
: Caries or iatrogenic thermal trauma of the teeth have a significant impact on the dental pulp structure connected with stimulation of angiogenesis and lymphangiogenesis. Therefore, the aim of the study was to identify the difference in the rate of heat dissipation by vessels present in the dental pulp. : Freshly extracted healthy ( = 10) and carious ( = 14) molars and premolars were cut on a diamond saw and subjected to active thermographic examination and then subjected to lymphoscintigraphy and X-ray examination.
View Article and Find Full Text PDFAdv Skin Wound Care
January 2025
At University of Texas Southwestern Medical Center, Dallas, Texas, United States, Yi-Ting Tzen, PhD, is Assistant Professor, Department of Applied Clinical Research, Department of Physical Medicine and Rehabilitation, and Department of Orthopaedic Surgery; Wei-Han Tan, MD, is Assistant Professor, VA North Texas Health Care System, Dallas, and Department of Physical Medicine and Rehabilitation; Patricia T. Champagne, PhD, is Postdoctoral Fellow, Department of Applied Clinical Research and Department of Physical Medicine and Rehabilitation; Jijia Wang, PhD, is Assistant Professor, Department of Applied Clinical Research; and Merrine Klakeel, DO, is Assistant Professor, Department of Physical Medicine and Rehabilitation. Kath M. Bogie, DPhil, is Professor, Department of Orthopaedics, Case Western Reserve University, Cleveland, Ohio, United States, and VA Northeast Ohio Healthcare System, Cleveland. Timothy J. Koh, PhD, is Professor, Department of Kinesiology and Nutrition, University of Illinois at Chicago, Illinois, United States.
Objective: To identify markers associated with pressure injury (PrI) history in individuals with spinal cord injury (SCI) using two approaches: skin blood flow (SBF) response toward localized heating, and serum marker for insulin resistance.
Methods: For this cross-sectional, observational study of adults with chronic traumatic SCI at T12 and above, researchers recruited two groups of participants: with history of PrI (group 1), and without history of PrI (group 2). The study protocol included obtaining fasting blood samples and measurement of SBF at bilateral heels with localized heating of 42 °C for 30 minutes from all participants.
PLoS One
January 2025
Cardiometabolic, Exercise, and Lifestyle Laboratory, University of New Brunswick, Fredericton, NB, Canada.
Blood flow restriction training (BFRT) has been previously studied as an alternative form of resistance training to gain lean mass and improve performance outcomes. However, in all exercise studies of BFRT, the proportion of female participants represents only 17-29% of all research participants. This highlights a strong underrepresentation of females and the need for more knowledge on the impact of BFRT and sex differences.
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