Restrictiveness, a component of relationship dominance associated with monitoring and regulating partners' behavior, is a risk factor and accelerant of Intimate Partner Violence (IPV). Few studies, however, have examined in vivo physiological responses associated with restrictiveness. Toward this end, 105 romantic couples (N = 210) completed measures of restrictiveness and had their physiological responses recorded in anticipation of and during a dyadic interaction in which they discussed a hypothetical transitional period in which one person (the discloser) revealed to their partner (the responder) that they had just gotten into their dream school or was offered their dream job. Individuals high (vs. low) in restrictiveness exhibited physiological responses indicative of greater psychological challenge (e.g., elevated cardiac output and lower peripheral resistance) in anticipation of and during the conversation. In contrast, their partners exhibited greater physiological indicators of psychological threat in anticipation of (but not during) the conversation, particularly when assigned to the discloser role. Exploratory analyses of communication behaviors corroborated the physiological data. This research integrates the biopsychosocial model of challenge and threat with theories of relationship power and dominance to demonstrate the physiological manifestations of a well-known risk factor for IPV in romantic relationships and interpersonal restrictiveness.
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Heart Vessels
January 2025
Department of Cardiology, Fujian Medical University Union Hospital, Fujian Institute of Coronary Heart Disease, Fujian Heart Medical Center, Fuzhou, 350001, Fujian, China.
Left bundle branch pacing (LBBP) is an emerging physiological pacing technique characterized by stable pacing parameters and a narrower QRS duration. This study aims to compare the long-term efficacy and safety of biventricular pacing (BIVP) and LBBP in patients with heart failure with reduced ejection fraction (HFrEF) and complete left bundle branch block (CLBBB). A retrospective analysis was conducted on 35 patients with chronic HFrEF accompanied by CLBBB treated at our center from April 2018 to October 2022.
View Article and Find Full Text PDFJ Comp Physiol B
January 2025
Departamento de Fisiologia, Instituto de Biociências da Universidade de São Paulo, São Paulo, Brazil.
During the transition from fresh waters to terrestrial habitats, significant adaptive changes occurred in kidney function of vertebrates to cope with varying osmotic challenges. We investigated the mechanisms driving water conservation in the mammalian nephron, focusing on the relative contributions of active ion transport and Starling forces. We constructed a thermodynamic model to estimate the entropy generation associated with different processes within the nephron, and analyzed their relative importance in urine formation.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
The University of Arizona - Tucson, Tucson, AZ, USA.
Background: Host commensal gut microbes are shown to be crucial for microglial maturation, and functions that involve innate immune responses to maintain brain homeostasis. Sex has a crucial role in the incidence of neurological diseases with females showing higher progression of AD compared with males. Transcriptomics has been a powerful tool for the characterization of microglial phenotypes however, there is a large gap in relating to their functional protein abundances.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Cornell University, Ithaca, NY, USA.
Background: Spatial disorientation is an early symptom of Alzheimer's disease (AD). The hippocampus creates a cognitive map, wherein cells form firing fields in specific locations within an environment, termed place cells. Critically, place cells remain stable across visits to an environment, but change their firing rate or field location in a different environment.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Manitoba, Winnipeg, MB, Canada.
Background: Mitochondrial bioenergetics are essential for cellular function, specifically the intricacies of the electron transport chain (ETC), with Complex IV playing a crucial role in unraveling the mechanisms governing energy production. Mathematical models offer a valuable approach to simulate these complex processes, providing insights into normal mitochondrial function and aberrations associated with various diseases, including neurodegenerative disorders. Our research focuses on introducing and refining a mathematical model, emphasizing Complex IV in the ETC, with objectives including incorporating mitochondrial activity modulation using inhibiting and uncoupling reagents, akin to oxygen consumption experiments.
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