AI Article Synopsis
- Fusarium fungi are harmful plant pathogens that significantly impact various crops, leading to substantial economic losses.
- Phenamacril is an effective new fungicide, but resistant strains of Fusarium have started to emerge, making it less effective.
- The study identified that modifications to the original phenamacril compound typically resulted in a significant reduction in its antifungal effectiveness, particularly against resistant strains.
Article Abstract
Filamentous fungi belonging to the genus Fusarium are notorious plant-pathogens that infect, damage and contaminate a wide variety of important crops. Phenamacril is the first member of a novel class of single-site acting cyanoacrylate fungicides which has proven highly effective against important members of the genus Fusarium. However, the recent emergence of field-resistant strains exhibiting qualitative resistance poses a major obstacle for the continued use of phenamacril. In this study, we synthesized novel cyanoacrylate compounds based on the phenamacril-scaffold to test their growth-inhibitory potential against wild-type Fusarium and phenamacril-resistant strains. Our findings show that most chemical modifications to the phenamacril-scaffold are associated with almost complete loss of fungicidal activity and in vitro inhibition of myosin motor domain ATPase activity.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323951 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235568 | PLOS |
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