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Ageing, clinical complexity, and exercise therapy: a multidimensional approach.
Front Sports Act Living
January 2025
Department of Internal Medicine, National Relevance and High Specialization Hospital Trust, ARNAS Civico, Di Cristina, Benfratelli, Palermo, Italy.
Ageing is a multidimensional concept related to the progressive decline in physiological functions. The decrease of physical autonomy due to the ageing process leads to frailty, which in turn is associated with disability and comorbidity. Ageing represents the primary risk factor for chronic degenerative diseases, especially involving cardiovascular, metabolic, respiratory, and osteoarticular systems, determining the decrease in activities and quality of daily life.
View Article and Find Full Text PDFeHealth tools to assess the neurological function for research, in absence of the neurologist: a systematic review, part II (hardware).
J Neurol
January 2025
Department of Sustainable Health, University of Groningen, Campus Fryslân, Wirdumerdijk 34, 8911 CE, Leeuwarden, The Netherlands.
Background: Neurological disorders pose a substantial burden worldwide in healthcare and health research. eHealth has emerged as a promising field given its potential to aid research, with lower resources. With a changing eHealth landscape, identifying available tools is instrumental for informing future research.
View Article and Find Full Text PDFSynthesis and discovery of simplified pleurotin analogs bearing tricyclic core as novel thioredoxin reductase inhibitors.
Eur J Med Chem
January 2025
Laboratory of Medicinal Chemical Biology, Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Suzhou Medical College, Soochow University, 199 Ren'ai Road, Suzhou, 215123, PR China. Electronic address:
Pleurotin (1) is a benzoquinone meroterpenoid known for its wide-spectrum antitumor and antibiotic activities, notably acting as natural inhibitors of the thioredoxin reductase (TrxR). Pleurotin (1) has been chemically synthesized, but only in milligram quantities through at least 13 longest linear steps with 0.8 % overall yield due to its complex structure such as fused hexacyclic core with 8 contiguous stereocenters.
View Article and Find Full Text PDFYou Win Some, You Lose Some: Modifying the Molecular Periphery of Nitrofuran-Tagged Diazaspirooctane Reshapes Its Antibacterial Activity Profile.
Int J Mol Sci
December 2024
Department of Medical Chemistry, Institute of Chemistry, Saint Petersburg State University, Saint Petersburg 199034, Russia.
The use of the concept of privileged structures significantly accelerates the search for new leads and their optimization. 6-(methylsulfonyl)-8-(4-methyl-4-1,2,4-triazol-3-yl)-2-(5-nitro-2-furoyl)-2,6-diazaspiro[3.4]octane has been identified as a lead, with MICs of 0.
View Article and Find Full Text PDFMeasurement of divertor surface heat flux by infra-red thermographic inversion in ST40.
Rev Sci Instrum
January 2025
Plasma Prediction and Simulation Department, Tokamak Energy Ltd., 173 Brook Drive, Milton Park, Abingdon OX14 4SD, United Kingdom.
Diagnostic tools for understanding the edge plasma behavior in fusion devices are essential. The main focus of the present work is to present the infra-red (IR) diagnostics installed on Tokamak Energy's spherical tokamak (ST40) and the IR thermographic inversion tool, Functional Analysis of Heat Flux (FAHF). FAHF is designed for multi-2D thermographic inversions within the divertor tiles using the finite difference method and an explicit time stepping scheme.
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