In this work, the new diaminochromenes: 2,5-dimono-8-methoxychromeno[4,3,2-][1,6]naphthyridine-4-carbonitrile (), 8-ethoxy-2-imino-3,4-dihydro-2-chromene-3-carbonitrile-4-malononitrile (), 2,5-diamino-8-ethoxychromene[4,3,2-][1,6]naphthyridine-4-carbonotrile (), were synthesized and fully characterized through 600 MHz using H, C, APT, gHSQC, gHMBC, ROESY-1D and gated decoupling C. Further docking studies suggested that these compounds are capable of intercalating with the Drew-Dickerson Dodecamer DNA and, therefore, be candidates to work as effective compounds to decrease the cancer radiotherapy.Communicated by Ramaswamy H. Sarma.

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http://dx.doi.org/10.1080/07391102.2020.1784284DOI Listing

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