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| http://dx.doi.org/10.3389/fnmol.2020.00091 | DOI Listing |
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Geographic variation of recorded neurodevelopmental disorders in children and adults.
Dan Med J
November 2024
NCRR - National Centre for Register-based Research, School of Business and Social Sciences, Aarhus University.
Introduction: While diagnosis rates of autism spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD) vary within countries at a large-scale municipal level, small neighbourhood geographic variation remains understudied. In this nationwide study, we describe the rates of ASD and ADHD diagnoses in children and adults by geographical data zones of approximately 2,500 residents across Denmark.
Methods: We included a population of children born from 1993 through 2020 and an adult population born from 1977 through 2003.
Analysis of exonic deletions in a large population study provides novel insights into NRXN1 pathology.
NPJ Genom Med
December 2024
Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Roskilde, Denmark.
The NRXN1 locus is a hotspot for non-recurrent copy number variants and exon-disrupting NRXN1 deletions have been associated with increased risk of neurodevelopmental disorders in case-control studies. However, corresponding population-based estimates of prevalence and disease-associated risk are currently lacking. Also, most studies have not differentiated between deletions affecting exons of different NRXN1 splice variants nor considered intronic deletions.
View Article and Find Full Text PDFThe longitudinal association between reward processing and symptoms of video game addiction in the Adolescent Brain Cognitive Development Study.
J Behav Addict
December 2024
1The Frederick J. and Marion A. Schindler Cognitive Neurophysiology Laboratory, The Ernest J. Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Background And Aims: Video games are a common form of entertainment in adolescents, which may result in gaming habits characterized by impairment to reward-related decision-making. The aim of the current study was to investigate the relationship between reward processing and symptoms of gaming addiction in adolescents.
Methods: Data from three consecutive follow-up years (years 2, 3 and 4) of the Adolescent Brain Cognitive Development (ABCD) Study were analyzed (n = 6,143, total observations = 12,745, mean age at year-2 = 12 years).
Associations between mesolimbic connectivity, and alcohol use from adolescence to adulthood.
Dev Cogn Neurosci
December 2024
Department of Psychiatry, Oregon Health & Science University, Portland, OR, United States; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States.
Dopaminergic projections from the ventral tegmental area (VTA) to limbic regions play a key role in the initiation and maintenance of substance use; however, the relationship between mesolimbic resting-state functional connectivity (RSFC) and alcohol use during development remains unclear. We examined the associations between alcohol use and VTA RSFC to subcortical structures in 796 participants (12-21 years old at baseline, 51 % female) across 9 waves of longitudinal data from the National Consortium on Alcohol and Neurodevelopment in Adolescence. Linear mixed effects models included interactions between age, sex, and alcohol use, and best fitting models were selected using log-likelihood ratio tests.
View Article and Find Full Text PDFHemochromatosis neural archetype reveals iron disruption in motor circuits.
Sci Adv
November 2024
Center for Multimodal Imaging and Genetics, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA.
Our understanding of brain iron regulation and its disruption in disease is limited. Excess iron affects motor circuitry, contributing to Parkinson's disease (PD) risk. The molecular mechanisms regulating central iron levels, beyond a few well-known genes controlling peripheral iron, remain unclear.
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