AI Article Synopsis
- The research focuses on a new method for ortho C-H borylation of aromatic phosphonates, utilizing simple starting materials and easily available catalysts.
- This technique allows for the creation of -phosphonate arylboronic esters that have diverse functional groups and substitution patterns.
- These newly formed products are versatile intermediates, enabling the synthesis of a wide array of highly substituted phosphoarenes, along with potential further modifications.
Article Abstract
Phosphonate-directed ortho C-H borylation of aromatic phosphonates is reported. Using simple starting materials and commercially accessible catalysts, this method provides steady access to -phosphonate arylboronic esters bearing pendant functionality and flexible substitution patterns. These products serve as flexible precursors for a variety of highly substituted phosphoarenes, and in situ downstream functionalization of the products is described.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405988 | PMC |
| http://dx.doi.org/10.1021/jacs.0c04159 | DOI Listing |
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