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Acute and mid-term outcome of ethanol infusion of vein of Marshall for the treatment of perimitral flutter. | LitMetric

AI Article Synopsis

  • Researchers studied 103 patients with perimitral flutter (PMF) to compare outcomes of two treatments: radiofrequency (RF) ablation alone versus an epicardial approach with ethanol infusion in the vein of Marshall (EIVOM) followed by RF ablation.
  • Both groups had similar rates of flutter termination, but the EIVOM/RF group achieved mitral isthmus block more frequently and required less RF duration for conversion.
  • A one-year follow-up showed that the EIVOM/RF group had significantly fewer recurrences of atrial tachycardia compared to the RF group, suggesting that EIVOM may enhance treatment results for PMF without severe complications.

Article Abstract

Aims: We hypothesized that an epicardial approach using ethanol infusion in the vein of Marshall (EIVOM) may improve the result of ablation for perimitral flutter (PMF).

Methods And Results: We studied 103 consecutive patients with PMF undergoing high-resolution mapping. The first 71 were treated with radiofrequency (RF) ablation alone (RF-group), and the next 32 underwent EIVOM followed by RF on the endocardial and epicardial mitral isthmus (EIVOM/RF-group). Contact force was not measured during ablation. Acute and 1-year outcomes were compared. Flutter termination rates were similar between the RF-group (63/71, 88.7%) and EIVOM/RF-group (31/32, 96.8%, P = 0.27). Atrial tachycardia (AT) terminated with EIVOM alone in 22/32 (68.6%) in the EIVOM/RF-group. Bidirectional block of mitral isthmus was always achieved in the EIVOM/RF-group, but significantly less frequently achieved in the RF-group (62/71, 87.3%; P = 0.05). Median RF duration for AT termination/conversion was shorter [0 (0-6) s in the EIVOM/RF-group than 312 (55-610) s in the RF-group, P < 0.0001], as well as for mitral isthmus block in the EIVOM/RF-group [246 (0-663) s] than in the RF-group [900 (525-1310) s, P < 0.0001]. Pericardial effusion was observed in 1/32 (3.2%) in EIVOM/RF-group and 5/71 (7.0%) in RF-group (P = 0.66); two in RF-group required drainage and one of them developed subsequent ischaemic stroke. One-year follow-up demonstrated fewer recurrences in the EIVOM/RF-group [6/32 (18.8%)] than in the RF-group [29/71 (40.8%), P = 0.04]. By multivariate analysis, only EIVOM was significantly associated with less AT recurrence (hazard ratio = 0.35, P = 0.018).

Conclusion: Ethanol infusion in the vein of Marshall may reduce RF duration required for PMF termination as well as for mitral isthmus block without severe complications, and the mid-term outcome may be improved by this approach.

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Source
http://dx.doi.org/10.1093/europace/euaa137DOI Listing

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