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A multicenter study on TROP2 as a potential targeted therapy for extramammary Paget disease in Japan.
Sci Rep
January 2025
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Extramammary Paget disease (EMPD) is a rare skin cancer that typically occurs in the anogenital area of older people. Since efficacy of treatments for metastatic or unresectable EMPD remains poor, development of a novel therapeutic approach is strongly desired. However, the lack of EMPD models has hampered investigation of EMPD.
View Article and Find Full Text PDFMaculopathies: A Systematic Literature Review on Pathophysiology, Public Health, and Treatment.
Cureus
December 2024
Ophthalmology, Ramsay Health Care, Mount Stuart Hospital, Torquay, GBR.
Macular degeneration (MD) is a pathological condition affecting the macula, an area located near the center of the retina. This disease affects individuals of all ages, both children and adults, causing severe visual impairment. Age-related macular degeneration (AMD) is the leading cause of visual loss in the older population while Stargardt disease (SD) is the most common hereditary maculopathy with an autosomal dominant pattern of inheritance.
View Article and Find Full Text PDFDevelopment of Paget's disease of bone in adults inheriting mutations: a long-term follow-up.
JBMR Plus
January 2025
Department of Medicine, FMHS, University of Auckland, Auckland 1023, New Zealand.
In a 2015 study of mutation carriers who had initial negative bone scintigraphy, we found that the rate of development of Paget's disease of bone (PDB) over 5 yr was low. We report here an additional 8-yr follow-up of this cohort, exploring the hypothesis that the rate of development of PDB would increase as the cohort aged. In the current study, 21 of 24 subjects from 2015 who had a negative bone scintiscan at baseline and at first follow-up, had a repeat scintiscan and measurement of total serum alkaline phosphatase activity.
View Article and Find Full Text PDFArticle Synopsis
- An 82-year-old woman with a history of bladder cancer had a cystectomy and developed a ureteral fistula in 2012, showing no cancer spread at that time.
- In 2020, she experienced vulvar itching, diagnosed as vulvovaginitis, but the symptoms persisted, leading to a biopsy in 2023 that revealed Paget cells and secondary extramammary Paget's disease linked to urothelial carcinoma.
- After detecting a mass in the pelvic floor and confirming local recurrence of cancer, she underwent surgery in October 2023 and is currently recovering well without signs of recurrence.
The clinical and pathological significance of tertiary lymphoid structure in extramammary Paget's disease.
Front Immunol
December 2024
Department of Pathology, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Background: Tumor-associated tertiary lymphoid structures (TLSs) are functional immune-responsive aggregates, which have been reported to be associated with better prognosis in various tumors. However, their exact characteristics and prognostic value in extramammary Paget's disease (EMPD) remain unknown.
Objective: To explore the features of TLSs in EMPD and their association with clinicopathological characteristics.
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