Short-term administration of hydrocortisone into rats (within 7 days) stimulated 1.25(OH)2D3 synthesis in kidney and led to accumulation of the metabolite in blood serum, small intestinal mucose and bones. After long-term administration of hydrocortisone within 28 days synthesis of 1.25(OH2D3) was decreased in kidney while the content of 24.25(OH)2D3 was was simultaneously increased. Concentration of labelled 1.25 (OH)2D3 and 24.25(OH)2D3 was distinctly decreased in small intestinal mucose and femur bones.
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